ANKRD13D

Protein identityUniProt · HPA

UniProt accession

Q6ZTN6

Gene

ANKRD13D

Ensembl

ENSG00000172932

Chromosome

11

Canonical length

605 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q6ZTN6|ANKRD13D
     1  MAGPGPTFPL HRLVWANRHR ELEAALHSHQ HDIEQEDPRG RTPLELAVSL GNLESVRVLL
    61  RHNANVGKEN RQGWAVLQEA VSTGDPEMVQ LVLQYRDYQR ATQRLAGIPE LLNKLRQAPD
   121  FYVEMKWEFT SWVPLVSKMC PSDVYRVWKR GESLRVDTSL LGFEHMTWQR GRRSFIFKGQ
   181  EAGALVMEVD HDRQVVHVET LGLTLQEPET LLAAMRPSEE HVASRLTSPI VSTHLDTRNV
   241  AFERNKCGIW GWRSEKMETV SGYEAKVYSA TNVELVTRTR TEHLSDQDKS RSKAGKTPFQ
   301  SFLGMAQQHS SHTGAPVQQA ASPTNPTAIS PEEYFDPNFS LESRNIGRPI EMSSKVQRFK
   361  ATLWLSEEHP LSLGDQVTPI IDLMAISNAH FAKLRDFITL RLPPGFPVKI EIPLFHVLNA
   421  RITFSNLCGC DEPLSSVWVP APSSAVAASG NPFPCEVDPT VFEVPNGYSV LGMERNEPLR
   481  DEDDDLLQFA IQQSLLEAGT EAEQVTVWEA LTNTRPGARP PPQATVYEEQ LQLERALQES
   541  LQLSTEPRGP GSPPRTPPAP GPPSFEEQLR LALELSSREQ EERERRGQQE EEDLQRILQL
   601  SLTEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD13D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.43

gnomAD pLI

0.35

gnomAD missense Z

1.64

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of receptor internalization

Molecular functions

• ubiquitin-modified protein reader activity

Cellular components

• cytoplasm
• late endosome
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ubiquitin interacting motif
• Ankyrin repeat domain-containing protein 13
• Ankyrin repeat-containing domain superfamily
• Ankyrin repeat domain-containing protein 13, C-terminal
• ANKRD13 C-terminal
• Ankyrin repeats (3 copies)

KeywordsUniProt

• ANK repeat
• Cell membrane
• Endosome
• Membrane
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ANKRD13D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EGFR