Seroatlas · Human Serome Atlas

ANKRD13C

Ankyrin repeat domain-containing protein 13C

Also known as: AN13C_HUMAN, dJ677H15.3, DKFZP566D1346

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6S4
Gene
ANKRD13C
Ensembl
ENSG00000118454
Chromosome
1
Canonical length
541 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables signaling receptor binding activity. Involved in protein retention in ER lumen; regulation of anoikis; and regulation of signaling receptor activity. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q8N6S4|ANKRD13C
     1  MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC HKIFSNHHHR
    61  LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP VAVVADGGSC PAHYPVHECV
   121  FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL AVMLGNKECA HLLLAHNAPV KVKNAQGWSP
   181  LAEAISYGDR QMITALLRKL KQQSRESVEE KRPRLLKALK ELGDFYLELH WDFQSWVPLL
   241  SRILPSDACK IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV
   301  YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK TERVGNFLAD
   361  FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGNIM EQNFEPIRRQ SLTPPPQNTI
   421  TWEEYISAEN GKAPHLGREL VCKESKKTFK ATIAMSQEFP LGIELLLNVL EVVAPFKHFN
   481  KLREFVQMKL PPGFPVKLDI PVFPTITATV TFQEFRYDEF DGSIFTIPDD YKEDPSRFPD
   541  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD13C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 13 nTPM
  • retina: 12 nTPM
  • cerebral cortex: 10 nTPM
  • skin: 9.4 nTPM
  • adipose tissue: 9.2 nTPM
  • ovary: 8.9 nTPM

Single-cell type

  • myonuclei: 207 nCPM
  • pituicytes/fscs: 149 nCPM
  • cone photoreceptor cells: 147 nCPM
  • rod photoreceptor cells: 132 nCPM
  • brain excitatory neurons: 127 nCPM
  • thyrotrophs: 125 nCPM

Immune cell

  • basophil: 15 nTPM
  • T-reg: 14 nTPM
  • MAIT T-cell: 13 nTPM
  • memory CD4 T-cell: 11 nTPM
  • memory CD8 T-cell: 11 nTPM
  • myeloid DC: 11 nTPM

Brain region

  • cerebellum: 29 nTPM
  • white matter: 25 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 23 nTPM
  • hypothalamus: 21 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
2.37
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD13C as an antibody target. Whether an autoantibody or antibody against ANKRD13C could matter depends on whether native ANKRD13C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD13C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD13C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD13C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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