Seroatlas · Human Serome Atlas

ANKRD13B

Ankyrin repeat domain-containing protein 13B

Also known as: AN13B_HUMAN, FLJ25555

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86YJ7
Gene
ANKRD13B
Ensembl
ENSG00000198720
Chromosome
17
Canonical length
626 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Enables ubiquitin-modified protein reader activity. Involved in negative regulation of receptor internalization. Located in endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q86YJ7|ANKRD13B
     1  MIPANASARK GPEGKYPLHY LVWHNRHREL EKEVRAGQVD IEQLDPRGRT PLHLATTLGH
    61  LECARVLLAH GADVGRENRS GWTVLQEAVS TRDLELVQLV LRYRDYQRVV KRLAGIPVLL
   121  EKLRKAQDFY VEMKWEFTSW VPLVSKICPS DTYKVWKSGQ NLRVDTTLLG FDHMTWQRGN
   181  RSFVFRGQDT SAVVMEIDHD RRVVYTETLA LAGQDRELLL AAAQPTEEQV LSRLTAPVVT
   241  TQLDTKNISF ERNKTGILGW RSEKTEMVNG YEAKVYGASN VELITRTRTE HLSEQHKGKV
   301  KGCKTPLQSF LGIAEQHGGP QNGTLITQTL SQANPTAITA EEYFNPNFEL GNRDMGRPME
   361  LTTKTQKFKA KLWLCEEHPL SLCEQVAPII DLMAVSNALF AKLRDFITLR LPPGFPVKIE
   421  IPIFHILNAR ITFGNLNGCD EPVPSVRGSP SSETPSPGSD SSSVSSSSST TSCRGCEISP
   481  ALFEAPRGYS MMGGQREAAT RDDDDDLLQF AIQQSLLEAG SEYDQVTIWE ALTNSKPGTH
   541  PMSYEGRRQD RSAPPTPQRQ PAPPASVPSP RPSSGPGSGG HVFRSYDEQL RLAMELSAQE
   601  QEERRRRARQ EEEELERILR LSLTEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD13B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 44 nTPM
  • cerebral cortex: 17 nTPM
  • spinal cord: 15 nTPM
  • basal ganglia: 12 nTPM
  • hippocampal formation: 11 nTPM
  • ovary: 9.5 nTPM

Single-cell type

  • late spermatids: 3 nCPM
  • endometrial stromal cells: 1.1 nCPM
  • mesothelial cells: 0.5 nCPM
  • decidual stromal cells: 0.4 nCPM
  • schwann cells: 0.4 nCPM
  • brain excitatory neurons: 0.3 nCPM

Immune cell

  • memory CD8 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 57 nTPM
  • cerebral cortex: 44 nTPM
  • hippocampal formation: 41 nTPM
  • medulla oblongata: 40 nTPM
  • amygdala: 38 nTPM
  • cerebellum: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.36
gnomAD missense Z
3.2
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD13B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD13B as an antibody target. Whether an autoantibody or antibody against ANKRD13B could matter depends on whether native ANKRD13B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD13B is annotated at the cell surface, where native ANKRD13B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANKRD13B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD13B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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