Seroatlas · Human Serome Atlas

ANKRD12

Ankyrin repeat domain-containing protein 12

Also known as: ANCO-2, ANR12_HUMAN, FLJ20053, GAC-1, KIAA0874

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UB98
Gene
ANKRD12
Ensembl
ENSG00000101745
Chromosome
18
Canonical length
2062 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

2062 residues, UniProt reviewed canonical sequence.

>Q6UB98|ANKRD12
     1  MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK EMKEKSSMKR
    61  KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY SEKEGPEKKK TKKEAGNKKS
   121  TPVSILFGYP LSERKQMALL MQMTARDNSP DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK
   181  RNERGETPLH MAAIRGDVKQ VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA
   241  GADVNTQGLD DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
   301  KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS KTPLPSALDE
   361  YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA KQEKAFYPKS FKSKKQKPSR
   421  VLYSSTESSD EEALQNKKIS TSCSVIPETS NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN
   481  KNKENQELKQ EKEGKENTRI TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST
   541  GKSPKHSCGL SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC
   601  KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL KKHKLKHKER
   661  EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF FKSDETEDLF LNMEHESLTL
   721  EKKSKLEKNI KDDKSTKEKH VSKERNFKEE RDKIKKESEK SFREEKIKDL KEERENIPTD
   781  KDSEFTSLGM SAIEESIGLH LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT
   841  FEKEKKIKHE HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR
   901  EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK NKEKDRELDK
   961  KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL KEKTKDEPLK TPDGKEKDKK
  1021  DKDIDRYKER DKHKDKIQIN SLLKLKSEAD KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF
  1081  ERMLSLKDLE IEQWHKKHKE KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR
  1141  SKSSEVTDAY TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS
  1201  SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL SIAKSPALHE
  1261  RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE GRPTIEVRRC SMPSVICEHT
  1321  KQFQTISEES NQGSLLTVPG DTSPSPKPEV FSNVPERDLS NVSNIHSSFA TSPTGASNSK
  1381  YVSADRNLIK NTAPVNTVMD SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN
  1441  IPDQESSLQS FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS
  1501  DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV LGDVQKTDAF
  1561  VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL NTHYAFSKLT YKSSSGHEVE
  1621  NSTTDTQVIS HEKENKLESL VLTHLSRCDS DLCEMNAGMP KGNLNEQDPK HCPESEKCLL
  1681  SIEDEESQQS ILSSLENHSQ QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA
  1741  NTMANQSKQI LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP
  1801  SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR KLLCSVIPQA
  1861  PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFRQQEVVR MKLRLQHSIE
  1921  REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDSQS DDSKTSVRDR
  1981  FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI
  2041  YEIQEFYVPL VDVNDDFELT PI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • retina: 28 nTPM
  • testis: 26 nTPM
  • skeletal muscle: 25 nTPM
  • lymph node: 21 nTPM
  • appendix: 19 nTPM
  • bone marrow: 19 nTPM

Single-cell type

  • podocytes: 424 nCPM
  • neutrophils: 413 nCPM
  • epididymal basal cells: 383 nCPM
  • late spermatids: 374 nCPM
  • respiratory ionocytes: 358 nCPM
  • renal collecting duct intercalated cells: 346 nCPM

Immune cell

  • neutrophil: 159 nTPM
  • basophil: 103 nTPM
  • eosinophil: 86 nTPM
  • memory B-cell: 64 nTPM
  • plasmacytoid DC: 61 nTPM
  • naive B-cell: 57 nTPM

Brain region

  • cerebellum: 188 nTPM
  • white matter: 125 nTPM
  • cerebral cortex: 118 nTPM
  • basal ganglia: 105 nTPM
  • hypothalamus: 100 nTPM
  • amygdala: 99 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
0.56
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD12 as an antibody target. Whether an autoantibody or antibody against ANKRD12 could matter depends on whether native ANKRD12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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