ANKRD1

Protein identityUniProt · HPA

UniProt accession

Q15327

Gene

ANKRD1

Ensembl

ENSG00000148677

Chromosome

10

Canonical length

319 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q15327|ANKRD1
     1  MMVLKVEELV TGKKNGNGEA GEFLPEDFRD GEYEAAVTLE KQEDLKTLLA HPVTLGEQQW
    61  KSEKQREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVVKEP EPEIITEPVD
   121  VPTFLKAALE NKLPVVEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE
   181  FRDMLESTAI HWASRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA
   241  CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LIMYGADLNI KNCAGKTPMD LVLHWQNGTK
   301  AIFDSLRENS YKTSRIATF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

6,126 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

0.19

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cardiac muscle tissue morphogenesis
• cellular response to hypoxia
• cellular response to interleukin-1
• cellular response to lipopolysaccharide
• cellular response to mechanical stimulus
• cellular response to transforming growth factor beta stimulus
• cellular response to tumor necrosis factor
• cellular response to xenobiotic stimulus
• negative regulation of DNA biosynthetic process
• negative regulation of transcription by RNA polymerase II
• phospholipase C/protein kinase C signal transduction
• positive regulation of apoptotic process
• positive regulation of DNA damage response, signal transduction by p53 class mediator
• positive regulation of neuron projection development
• positive regulation of protein secretion
• regulation of transcription by RNA polymerase II
• response to muscle stretch
• sarcomere organization
• skeletal muscle cell differentiation

Molecular functions

• DNA binding
• histone deacetylase binding
• p53 binding
• R-SMAD binding
• RNA polymerase II-specific DNA-binding transcription factor binding
• titin binding
• transcription coactivator activity
• transcription corepressor activity

Cellular components

• cytoplasm
• cytosol
• fibrillar center
• I band
• nucleoplasm
• nucleus
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• Ankyrin repeats (3 copies)

KeywordsUniProt

• ANK repeat
• Coiled coil
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ANKRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YBX1
• TTN