Seroatlas · Human Serome Atlas

ANKMY2

Ankyrin repeat and MYND domain-containing protein 2

Also known as: ANKY2_HUMAN, DKFZP564O043, ZMYND20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV38
Gene: ANKMY2
Ensembl: ENSG00000106524
Chromosome: 7
Canonical length: 441 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable enzyme binding activity and zinc ion binding activity. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q8IV38|ANKMY2
     1  MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLSSKNVRVN CLDENGMTPL MHAAYKGKLD
    61  MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA
   121  AFVGQHDCVT IINNFFPRER LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM
   181  LVNENPLLTE EAALNKCYRV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDGE
   241  NKLDTLIKSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA
   301  FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FTHKKICKNL
   361  KDIYEKQQLE AAKEKRQEEN HGKLDVNSNC VNEEQPEAEV GISQKDSNPE DSGEGKKESL
   421  ESEAELEGLQ DAPAGPQVSE E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKMY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 37 nTPM
stomach: 23 nTPM
skeletal muscle: 22 nTPM
tongue: 22 nTPM
retina: 22 nTPM
cerebral cortex: 21 nTPM

Single-cell type

choroid plexus epithelial cells: 99 nCPM
tuft cells: 92 nCPM
cone photoreceptor cells: 89 nCPM
late primary spermatocytes: 66 nCPM
rod photoreceptor cells: 65 nCPM
pituitary stem cells: 63 nCPM

Immune cell

basophil: 30 nTPM
eosinophil: 18 nTPM
NK-cell: 14 nTPM
non-classical monocyte: 12 nTPM
memory CD8 T-cell: 12 nTPM
gdT-cell: 12 nTPM

Brain region

cerebral cortex: 37 nTPM
basal ganglia: 31 nTPM
choroid plexus: 29 nTPM
white matter: 27 nTPM
cerebellum: 26 nTPM
hypothalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cilium

Protein domainsUniProt · Pfam · InterPro

Ankyrin repeat
Zinc finger, MYND-type
Ankyrin repeat-containing domain superfamily
MYND finger
Ankyrin repeats (3 copies)
Ankyrin repeat and MYND domain-containing protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKMY2 as an antibody target. Whether an autoantibody or antibody against ANKMY2 could matter depends on whether native ANKMY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKMY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKMY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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