Seroatlas · Human Serome Atlas

ANKMY1

Ankyrin repeat and MYND domain-containing protein 1

Also known as: ANKY1_HUMAN, FLJ20499, ZMYND13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2S6
Gene: ANKMY1
Ensembl: ENSG00000144504
Chromosome: 2
Canonical length: 941 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

941 residues, UniProt reviewed canonical sequence.

>Q9P2S6|ANKMY1
     1  MYQGEFGLNM KLGYGKFSWP TGESYHGQFY RDHCHGLGTY MWPDGSSFTG TFYLSHREGY
    61  GTMYMKTRLF QGLYKADQRF GPGVETYPDG SQDVGLWFRE QLIKLCTQIP SGFSLLRYPE
   121  FSSFITHSPA RISLSEEEKT EWGLQEGQDP FFYDYKRFLL NDNLTLPPEM YVYSTNSDHL
   181  PMTSSFRKEL DARIFLNEIP PFVEDGEPWF IINETPLLVK IQKQTYKFRN KPAHTSWNMG
   241  AILEGKRSGF APCGPKEQLS MEMILKAEEG NHEWICRILK DNFASADVAD AKGYTVLAAA
   301  ATHCHNDIVN LLLDCGADVN KCSDEGLTAL SMCFLLHYPA QSFKPNVAER TIPEPQEPPK
   361  FPVVPILSSS FMDTNLESLY YEVNVPSQGS YELRPPPAPL LLPRVSGSHE GGHFQDTGQC
   421  GGSIDHRSSS LKGDSPLVKG SLGHVESGLE DVLGNTDRGS LCSAETKFES NVCVCDFSIE
   481  LSQAMLERSA QSHSLLKMAS PSPCTSSFDK GTMRRMALSM IERRKRWRTI KLLLRRGADP
   541  NLCCVPMQVL FLAVKAGDVD GVRLLLEHGA RTDICFPPQL STLTPLHIAA ALPGEEGVQI
   601  VELLLHAITD VDAKASDEDD TYKPGKLDLL PSSLKLSNEP GPPQAYYSTD TALPEEGGRT
   661  ALHMACERED DNKCARDIVR LLLSHGANPN LLWSGHSPLS LSIASGNELV VKELLTQGAD
   721  PNLPLTKGLG SALCVACDLT YEHQRNMDSK LALIDRLISH GADILKPVML RQGEKEAVGT
   781  AVDYGYFRFF QDRRIARCPF HTLMPAERET FLARKRLLEY MGLQLRQAVF AKESQWDPTW
   841  LYLCKRAELI PSHRMKKKGP SLPRGLDVKE QGQIPFFKFC YQCGRSIGVR LLPCPRCYGI
   901  LTCSKYCKTK AWTEFHKKDC GDLVAIVTQL EQVSRRREEF Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKMY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
fallopian tube: 23 nTPM
bone marrow: 9.9 nTPM
choroid plexus: 8.8 nTPM
pancreas: 8.1 nTPM
lymph node: 8 nTPM

Single-cell type

late spermatids: 351 nCPM
respiratory ciliated cells: 332 nCPM
early spermatids: 296 nCPM
ependymal cells: 296 nCPM
endometrial ciliated cells: 184 nCPM
late primary spermatocytes: 170 nCPM

Immune cell

gdT-cell: 4.4 nTPM
eosinophil: 4.2 nTPM
naive CD4 T-cell: 4 nTPM
naive B-cell: 3.7 nTPM
naive CD8 T-cell: 2.8 nTPM
memory B-cell: 2.6 nTPM

Brain region

midbrain: 22 nTPM
white matter: 19 nTPM
spinal cord: 17 nTPM
pons: 15 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Ankyrin repeat
Zinc finger, MYND-type
MORN repeat
Ankyrin repeat-containing domain superfamily
MYND finger
MORN repeat
Ankyrin repeats (3 copies)
Ankyrin repeat and MYND domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKMY1 as an antibody target. Whether an autoantibody or antibody against ANKMY1 could matter depends on whether native ANKMY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKMY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKMY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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