Seroatlas · Human Serome Atlas

ANKAR

Ankyrin and armadillo repeat-containing protein

Also known as: ANKAR_HUMAN, FLJ25415

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5J8
Gene: ANKAR
Ensembl: ENSG00000151687
Chromosome: 2
Canonical length: 1434 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1434 residues, UniProt reviewed canonical sequence.

>Q7Z5J8|ANKAR
     1  MLRLPKKGLP RFEQVQDEDT YLENLAIQRN ASAFFEKYDR SEIQELLTTA LVSWLSAKED
    61  VRSQVDLPCG IMSQMNNVGF STAILLTPVD PTALLDYREV HQMIRELAIG IYCLNQIPSI
   121  SLEANYDQSS SCQLPPAYYD TRIGQILINI DYMLKALWHG IYMPKEKRAR FSELWRAIMD
   181  IDPDGKPQTN KDIFSEFSSA GLTDITKDPD FNEIYDEDVN EDPTYDPNSP EETAVFMKYA
   241  ENIMLKLTFS TTQIQQYENV FIFETGYWLT NAIKYNQDYL DICTYQRLQQ RLYLQKKIIQ
   301  KHFEKKKDIR RGIGYLKLIC FLIPFLLSLK KKMKVPYLSS LLQPFSDDKV KTERELPPFI
   361  YGRDFKCQNF HYKENQYFHV HGGIEFDIST PSIENALEDF QKNLEKIRDC AANTFIEDSG
   421  YKEYYSIPVM EFHGKSYYVI YFELETFYQQ LYKTQWWGAI NEIVNNLRLK RLPLTDAQLH
   481  EQFKKKLGFK RAMKCKSIPF GMKSAVERGL SAVFHTFSRK TSSSTINVSD EAGYTIFHHA
   541  ALHNRVSIIC QLCNANFKVN QRRFVTFSQG PTPLHLAAQA CSLETTVCLL CSKADYTLSE
   601  KRGWMPIHFA AFYDNVCIII ALCRKDPSLL EAEATAENQC TPLLLAATSG ALDTIQYLFS
   661  IGANWRKTDI KGNNIIHLSV LTFHTEVLKY IIKLNIPELP VWKTLVEMLQ CESYKRRMMA
   721  VMSLEVICLA NDQYWRCILD AGTIPALINL LKSSKIKLQC KTVGLLSNIS THKSAVHALV
   781  EAGGIPSLIN LLVCDEPEVH SRCAVILYDI AQCENKDVIA KYNGIPSLIN LLNLNIENVL
   841  VNVMNCIRVL CIGNENNQRA VREHKGLPYL IRFLSSDSDV LKAVSSAAIA EVGRDNKEIQ
   901  DAIAMEGAIP PLVALFKGKQ ISVQMKGAMA VESLASHNAL IQKAFLEKSL TKYLLKLLKA
   961  FQIDVKEQGA VALWALAGQT LKQQKYMAEQ IGYSFIINML LSPSAKMQYV GGEAVIALSK
  1021  DSRMHQNQIC EGNGIAPLVR LLRISTIAEG TLLSVIRAVG SICIGVAHTS NPVSQQLVVD
  1081  ENAFPVLIQL LRNHPSPNIK VEVAFSLACI VLGNDVLQKD LHENEGFEYA DVLYLLHSTE
  1141  KDICLRAGYA LTLFAFNNRF QQYLILESGI MTISIFERFL ESTVETEKAM AAFQIVVLAK
  1201  VIRDMDHITL SARGVTILVD SLYSVQTSTI VLTGNLIASL AHSRAGIPEA FTTLGTIQRL
  1261  CYHLYSGIEE VRAACSSALG YLTYNANAFR ILLKECRNKP NQFIRIKNNI SRDASINPAF
  1321  LKEFQMQQTL VGLPSLSLEK NGGPSIIPIF KRGKEHRRKL KPKIQPKDSL TLLPPVTNFM
  1381  GLFKATKKTK DSHNIFSFSS TITSDITNVS RPRIVCLNQL GKHVQKANPE PAEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

testis: 5.4 nTPM
epididymis: 0.6 nTPM
parathyroid gland: 0.6 nTPM
lymph node: 0.5 nTPM
retina: 0.5 nTPM
salivary gland: 0.5 nTPM

Single-cell type

fibro-adipogenic progenitors: 220 nCPM
myonuclei: 197 nCPM
bergmann glia: 160 nCPM
pituitary stem cells: 158 nCPM
adipocytes: 153 nCPM
thyrotrophs: 150 nCPM

Immune cell

naive B-cell: 0.4 nTPM
eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 3.8 nTPM
cerebellum: 3.1 nTPM
white matter: 2 nTPM
basal ganglia: 1.6 nTPM
pons: 1.6 nTPM
cerebral cortex: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.86
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Armadillo
Ankyrin repeat
Armadillo-like helical
Armadillo-type fold
Ankyrin repeat-containing domain superfamily
Armadillo/beta-catenin-like repeat
Ankyrin repeats (3 copies)
Ankyrin and armadillo repeat-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKAR as an antibody target. Whether an autoantibody or antibody against ANKAR could matter depends on whether native ANKAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKAR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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