Seroatlas · Human Serome Atlas

ANGPTL8

Angiopoietin-like protein 8

Also known as: ANGL8_HUMAN, C19orf80, RIFL, TD26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXH0
Gene
ANGPTL8
Ensembl
ENSG00000130173
Chromosome
19
Canonical length
198 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable hormone activity. Involved in regulation of lipid metabolic process and triglyceride homeostasis. Acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q6UXH0|ANGPTL8
     1  MPVPALCLLW ALAMVTRPAS AAPMGGPELA QHEELTLLFH GTLQLGQALN GVYRTTEGRL
    61  TKARNSLGLY GRTIELLGQE VSRGRDAAQE LRASLLETQM EEDILQLQAE ATAEVLGEVA
   121  QAQKVLRDSV QRLEVQLRSA WLGPAYREFE VLKAHADKQS HILWALTGHV QRQRREMVAQ
   181  QHRLRQIQER LHTAALPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPTL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
409 nTPM

Expression across tissuesHPA

Tissue

  • liver: 409 nTPM
  • adipose tissue: 32 nTPM
  • breast: 22 nTPM
  • blood vessel: 7.5 nTPM
  • kidney: 3.7 nTPM
  • heart muscle: 1.6 nTPM

Single-cell type

  • hepatocytes: 109 nCPM
  • cholangiocytes: 7.2 nCPM
  • adipocytes: 6.4 nCPM
  • epicardial cells: 2.3 nCPM
  • late spermatids: 2.1 nCPM
  • kupffer cells: 2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 8 nTPM
  • thalamus: 5.5 nTPM
  • amygdala: 5.3 nTPM
  • basal ganglia: 4.9 nTPM
  • hippocampal formation: 4.7 nTPM
  • medulla oblongata: 4.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANGPTL8.

Disease | AllUniProt

Conditions ANGPTL8 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Angiopoietin-like protein 8

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANGPTL8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGPTL8 as an antibody target. Whether an autoantibody or antibody against ANGPTL8 could matter depends on whether native ANGPTL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGPTL8 is annotated as secreted, so native ANGPTL8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ANGPTL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANGPTL8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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