ANGPTL7
Angiopoietin-related protein 7
Also known as: ANGL7_HUMAN, AngX, CDT6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43827
- Gene
- ANGPTL7
- Ensembl
- ENSG00000171819
- Chromosome
- 1
- Canonical length
- 346 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
346 residues, UniProt reviewed canonical sequence.
>O43827|ANGPTL7
1 MLKKPLSAVT WLCIFIVAFV SHPAWLQKLS KHKTPAQPQL KAANCCEEVK ELKAQVANLS
61 SLLSELNKKQ ERDWVSVVMQ VMELESNSKR MESRLTDAES KYSEMNNQID IMQLQAAQTV
121 TQTSADAIYD CSSLYQKNYR ISGVYKLPPD DFLGSPELEV FCDMETSGGG WTIIQRRKSG
181 LVSFYRDWKQ YKQGFGSIRG DFWLGNEHIH RLSRQPTRLR VEMEDWEGNL RYAEYSHFVL
241 GNELNSYRLF LGNYTGNVGN DALQYHNNTA FSTKDKDNDN CLDKCAQLRK GGYWYNCCTD
301 SNLNGVYYRL GEHNKHLDGI TWYGWHGSTY SLKRVEMKIR PEDFKPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANGPTL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 18 nTPM
- adipose tissue: 16 nTPM
- colon: 9.7 nTPM
- heart muscle: 7.4 nTPM
- skeletal muscle: 7.4 nTPM
- seminal vesicle: 6.2 nTPM
Single-cell type
- schwann cells: 44 nCPM
- fibroblasts: 43 nCPM
- ocular epithelial cells: 12 nCPM
- retinal ganglion cells: 12 nCPM
- mesothelial cells: 9.8 nCPM
- epicardial cells: 6.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- thalamus: 12 nTPM
- cerebellum: 6.4 nTPM
- midbrain: 3.8 nTPM
- hypothalamus: 3.4 nTPM
- medulla oblongata: 3.4 nTPM
- pons: 3.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.13
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- blood coagulation
- regulation of extracellular matrix organization
- response to oxidative stress
- negative regulation of vasculature development involved in avascular cornea development in camera-type eye
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANGPTL7 as an antibody target. Whether an autoantibody or antibody against ANGPTL7 could matter depends on whether native ANGPTL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANGPTL7 is annotated as secreted, so native ANGPTL7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ANGPTL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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