ANGPTL6
Angiopoietin-related protein 6
Also known as: AGF, ANGL6_HUMAN, ARP5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NI99
- Gene
- ANGPTL6
- Ensembl
- ENSG00000130812
- Chromosome
- 19
- Canonical length
- 470 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Predicted to enable signaling receptor binding activity. Predicted to be involved in angiogenesis; blood coagulation; and cell differentiation. Located in collagen-containing extracellular matrix and extracellular exosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
470 residues, UniProt reviewed canonical sequence.
>Q8NI99|ANGPTL6
1 MGKPWLRALQ LLLLLGASWA RAGAPRCTYT FVLPPQKFTG AVCWSGPAST RATPEAANAS
61 ELAALRMRVG RHEELLRELQ RLAAADGAVA GEVRALRKES RGLSARLGQL RAQLQHEAGP
121 GAGPGADLGA EPAAALALLG ERVLNASAEA QRAAARFHQL DVKFRELAQL VTQQSSLIAR
181 LERLCPGGAG GQQQVLPPPP LVPVVPVRLV GSTSDTSRML DPAPEPQRDQ TQRQQEPMAS
241 PMPAGHPAVP TKPVGPWQDC AEARQAGHEQ SGVYELRVGR HVVSVWCEQQ LEGGGWTVIQ
301 RRQDGSVNFF TTWQHYKAGF GRPDGEYWLG LEPVYQLTSR GDHELLVLLE DWGGRGARAH
361 YDGFSLEPES DHYRLRLGQY HGDAGDSLSW HNDKPFSTVD RDRDSYSGNC ALYQRGGWWY
421 HACAHSNLNG VWHHGGHYRS RYQDGVYWAE FRGGAYSLRK AAMLIRPLKLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANGPTL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- liver: 29 nTPM
- lymph node: 3.3 nTPM
- small intestine: 3.3 nTPM
- spleen: 3.3 nTPM
- tonsil: 3.2 nTPM
- bone marrow: 2.8 nTPM
Single-cell type
- epicardial cells: 41 nCPM
- hepatic stellate cells: 19 nCPM
- granulosa cells: 15 nCPM
- hepatocytes: 9.5 nCPM
- oocytes: 9.2 nCPM
- undifferentiated spermatogonia: 9.1 nCPM
Immune cell
- naive B-cell: 0.9 nTPM
- memory B-cell: 0.7 nTPM
- gdT-cell: 0.6 nTPM
- T-reg: 0.5 nTPM
- intermediate monocyte: 0.4 nTPM
- MAIT T-cell: 0.4 nTPM
Brain region
- white matter: 3.7 nTPM
- medulla oblongata: 3.6 nTPM
- pons: 2.8 nTPM
- spinal cord: 2.6 nTPM
- cerebral cortex: 2.4 nTPM
- thalamus: 2.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.19
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.57
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANGPTL6 as an antibody target. Whether an autoantibody or antibody against ANGPTL6 could matter depends on whether native ANGPTL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANGPTL6 is annotated as secreted, so native ANGPTL6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ANGPTL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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