Seroatlas · Human Serome Atlas

ANGPTL2

Angiopoietin-related protein 2

Also known as: ANGL2_HUMAN, ARP2, HARP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKU9
Gene: ANGPTL2
Ensembl: ENSG00000136859
Chromosome: 9
Canonical length: 493 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted to blood

OverviewNCBI Gene

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q9UKU9|ANGPTL2
     1  MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES QDKCTYTFIV
    61  PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV
   121  KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE
   181  HKYQHLATLA HNQSEIIAQL EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN
   241  EIQSDQNLKV LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN
   301  RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ
   361  GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD
   421  RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK
   481  VVMMIRPNPN TFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPTL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 105 nTPM
colon: 73 nTPM
breast: 70 nTPM
heart muscle: 65 nTPM
gallbladder: 63 nTPM
endometrium: 59 nTPM

Single-cell type

decidual stromal cells: 92 nCPM
fibro-adipogenic progenitors: 75 nCPM
fibroblasts: 73 nCPM
smooth muscle cells: 68 nCPM
cardiomyocytes: 61 nCPM
oligodendrocyte progenitor cells: 57 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 31 nTPM
cerebellum: 31 nTPM
thalamus: 26 nTPM
basal ganglia: 26 nTPM
choroid plexus: 26 nTPM
midbrain: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGPTL2 as an antibody target. Whether an autoantibody or antibody against ANGPTL2 could matter depends on whether native ANGPTL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGPTL2 is annotated as secreted, so native ANGPTL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ANGPTL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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