Seroatlas · Human Serome Atlas

ANGPTL1

Angiopoietin-related protein 1

Also known as: ANG3, ANGL1_HUMAN, ANGPT3, AngY, ARP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95841
Gene
ANGPTL1
Ensembl
ENSG00000116194
Chromosome
1
Canonical length
491 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>O95841|ANGPTL1
     1  MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI
    61  TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR
   121  KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA
   181  SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ
   241  RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
   301  SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS
   361  NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT
   421  LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL
   481  RAVQMMIKPI D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
125 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 125 nTPM
  • blood vessel: 78 nTPM
  • endometrium: 68 nTPM
  • smooth muscle: 61 nTPM
  • ovary: 55 nTPM
  • tongue: 54 nTPM

Single-cell type

  • leydig cells: 575 nCPM
  • peritubular myoid cells: 299 nCPM
  • b-cells: 281 nCPM
  • rod photoreceptor cells: 217 nCPM
  • decidual stromal cells: 206 nCPM
  • esophageal apical cells: 190 nCPM

Immune cell

  • naive B-cell: 0.6 nTPM
  • memory B-cell: 0.5 nTPM
  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hippocampal formation: 6.2 nTPM
  • basal ganglia: 5.6 nTPM
  • cerebral cortex: 5.2 nTPM
  • cerebellum: 4.9 nTPM
  • white matter: 4.8 nTPM
  • spinal cord: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.48
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANGPTL1 as an antibody target. Whether an autoantibody or antibody against ANGPTL1 could matter depends on whether native ANGPTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANGPTL1 is annotated as secreted, so native ANGPTL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ANGPTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANGPTL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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