ANGPT4

Protein identityUniProt · HPA

UniProt accession

Q9Y264

Gene

ANGPT4

Ensembl

ENSG00000101280

Chromosome

20

Canonical length

503 aa

Protein class

Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q9Y264|ANGPT4
     1  MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP KSEPCPPGPE
    61  VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW LKKLERAIKT ILRSKLEQVQ
   121  QQMAQNQTAP MLELGTSLLN QTTAQIRKLT DMEAQLLNQT SRMDAQMPET FLSTNKLENQ
   181  LLLQRQKLQQ LQGQNSALEK RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG
   241  LRGVRHNSSL LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS
   301  ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK QGFGDPAGEH
   361  WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG SENQLYRLSV VGYSGSAGRQ
   421  SSLVLQNTSF STLDSDNDHC LCKCAQVMSG GWWFDACGLS NLNGVYYHAP DNKYKMDGIR
   481  WHYFKGPSYS LRASRMMIRP LDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANGPT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

6.9 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.33

gnomAD pLI

0

gnomAD missense Z

-0.13

DepMap mean gene effect

0.14

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• blood coagulation
• cellular response to hypoxia
• negative regulation of angiogenesis
• negative regulation of apoptotic process
• negative regulation of blood vessel endothelial cell migration
• Notch signaling pathway
• positive regulation of angiogenesis
• positive regulation of blood vessel endothelial cell migration
• positive regulation of endothelial cell migration
• positive regulation of peptidyl-tyrosine phosphorylation
• signal transduction
• Tie signaling pathway

Molecular functions

• receptor ligand activity
• receptor tyrosine kinase binding
• transmembrane receptor protein tyrosine kinase activator activity

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
• Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
• Fibrinogen, conserved site
• Fibrinogen-like, C-terminal
• Fibrinogen/angiopoietin-like
• Angiopoietin-1/2/4 domain
• Fibrinogen beta and gamma chains, C-terminal globular domain
• ANG-1-like domain

KeywordsUniProt

• Angiogenesis
• Coiled coil
• Disulfide bond
• Glycoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of ANGPT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TEK