Seroatlas · Human Serome Atlas

AMZ1

Archaemetzincin-1

Also known as: AMZ1_HUMAN, KIAA1950

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q400G9
Gene: AMZ1
Ensembl: ENSG00000174945
Chromosome: 7
Canonical length: 498 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q400G9|AMZ1
     1  MLQCRPAQEF SFGPRALKDA LVSTDAALQQ LYVSAFSPAE RLFLAEAYNP QRTLFCTLLI
    61  RTGFDWLLSR PEAPEDFQTF HASLQHRKPR LARKHIYLQP IDLSEEPVGS SLLHQLCSCT
   121  EAFFLGLRVK CLPSVAAASI RCSSRPSRDS DRLQLHTDGI LSFLKNNKPG DALCVLGLTL
   181  SDLYPHEAWS FTFSKFLPGH EVGVCSFARF SGEFPKSGPS APDLALVEAA ADGPEAPLQD
   241  RGWALCFSAL GMVQCCKVTC HELCHLLGLG NCRWLRCLMQ GALSLDEALR RPLDLCPICL
   301  RKLQHVLGFR LIERYQRLYT WTQAVVGTWP SQEAGEPSVW EDTPPASADS GMCCESDSEP
   361  GTSVSEPLTP DAGSHTFASG PEEGLSYLAA SEAPLPPGGP AEAIKEHERW LAMCIQALQR
   421  EVAEEDLVQV DRAVDALDRW EMFTGQLPAT RQDPPSSRDS VGLRKVLGDK FSSLRRKLSA
   481  RKLARAESAP RPWDGEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

amygdala: 2.1 nTPM
cerebral cortex: 2.1 nTPM
basal ganglia: 1.5 nTPM
hippocampal formation: 1.5 nTPM
midbrain: 1.4 nTPM
hypothalamus: 1.1 nTPM

Single-cell type

oligodendrocyte progenitor cells: 242 nCPM
cardiomyocytes: 136 nCPM
fibro-adipogenic progenitors: 91 nCPM
epicardial cells: 89 nCPM
adipocytes: 88 nCPM
cdc: 88 nCPM

Immune cell

memory B-cell: 1.3 nTPM
naive B-cell: 0.7 nTPM
T-reg: 0.3 nTPM
basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 24 nTPM
amygdala: 24 nTPM
thalamus: 21 nTPM
midbrain: 17 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -3.59
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMZ1 as an antibody target. Whether an autoantibody or antibody against AMZ1 could matter depends on whether native AMZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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