Seroatlas · Human Serome Atlas

AMTN

Amelotin

Also known as: AMTN_HUMAN, RSTI689, UNQ689

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UX39
Gene
AMTN
Ensembl
ENSG00000187689
Chromosome
4
Canonical length
209 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q6UX39|AMTN
     1  MRSTILLFCL LGSTRSLPQL KPALGLPPTK LAPDQGTLPN QQQSNQVFPS LSLIPLTQML
    61  TLGPDLHLLN PAAGMTPGTQ THPLTLGGLN VQQQLHPHVL PIFVTQLGAQ GTILSSEELP
   121  QIFTSLIIHS LFPGGILPTS QAGANPDVQD GSLPAGGAGV NPATQGTPAG RLPTPSGTDD
   181  DFAVTTPAGI QRSTHAIEEA TTESANGIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 27 nTPM
  • stomach: 6.9 nTPM
  • salivary gland: 6.2 nTPM
  • prostate: 1.9 nTPM
  • esophagus: 0.4 nTPM
  • lung: 0.4 nTPM

Single-cell type

  • salivary basal cells: 38 nCPM
  • foveolar cells: 23 nCPM
  • salivary acinar cells: 11 nCPM
  • esophageal apical cells: 6.7 nCPM
  • salivary duct cells: 4.8 nCPM
  • prostatic glandular cells: 3.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.4 nTPM
  • midbrain: 0.9 nTPM
  • thalamus: 0.3 nTPM
  • choroid plexus: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • hypothalamus: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AMTN.

Disease | AllUniProt

Conditions AMTN is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Amelogenesis imperfecta type 3B

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Amelotin
  • Amelotin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMTN as an antibody target. Whether an autoantibody or antibody against AMTN could matter depends on whether native AMTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMTN is annotated as secreted, so native AMTN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AMTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMTN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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