Seroatlas · Human Serome Atlas

AMN

Protein amnionless

Also known as: amnionless, AMNLS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXJ7
Gene
AMN
Ensembl
ENSG00000166126
Chromosome
14
Canonical length
453 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9BXJ7|AMN
     1  MGVLGRVLLW LQLCALTQAV SKLWVPNTDF DVAANWSQNR TPCAGGAVEF PADKMVSVLV
    61  QEGHAVSDML LPLDGELVLA SGAGFGVSDV GSHLDCGAGE PAVFRDSDRF SWHDPHLWRS
   121  GDEAPGLFFV DAERVPCRHD DVFFPPSASF RVGLGPGASP VRVRSISALG RTFTRDEDLA
   181  VFLASRAGRL RFHGPGALSV GPEDCADPSG CVCGNAEAQP WICAALLQPL GGRCPQAACH
   241  SALRPQGQCC DLCGAVVLLT HGPAFDLERY RARILDTFLG LPQYHGLQVA VSKVPRSSRL
   301  READTEIQVV LVENGPETGG AGRLARALLA DVAENGEALG VLEATMRESG AHVWGSSAAG
   361  LAGGVAAAVL LALLVLLVAP PLLRRAGRLR WRRHEAAAPA GAPLGFRNPV FDVTASEELP
   421  LPRRLSLVPK AAADSTSHSY FVNPLFAGAE AEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
87 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 87 nTPM
  • liver: 55 nTPM
  • kidney: 52 nTPM
  • duodenum: 41 nTPM
  • colon: 37 nTPM
  • stomach: 7.5 nTPM

Single-cell type

  • enterocytes: 1,883 nCPM
  • colonocytes: 602 nCPM
  • epididymal efferent duct absorptive cells: 400 nCPM
  • goblet cells: 297 nCPM
  • enteric transient amplifying cells: 238 nCPM
  • breast lactating cells: 149 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 0.8 nTPM
  • pons: 0.8 nTPM
  • white matter: 0.8 nTPM
  • basal ganglia: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AMN.

Disease | AllUniProt

Conditions AMN is implicated in, by any mechanism.

Disease | GeneticClinVar

77 pathogenic / likely-pathogenic of 711 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Amnionless
  • Amnionless

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AMN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMN as an antibody target. Whether an autoantibody or antibody against AMN could matter depends on whether native AMN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMN is annotated at the cell surface, where native AMN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AMN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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