Seroatlas · Human Serome Atlas

AMMECR1L

AMMECR1-like protein

Also known as: AMERL_HUMAN, MGC4268

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DCA0
Gene: AMMECR1L
Ensembl: ENSG00000144233
Chromosome: 2
Canonical length: 310 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q6DCA0|AMMECR1L
     1  MGKRRCVPPL EPKLAAGCCG VKKPKLSGSG THSHGNQSTT VPGSSSGPLQ NHQHVDSSSG
    61  RENVSDLTLG PGNSPITRMN PASGALSPLP RPNGTANTTK NLVVTAEMCC YCFDVLYCHL
   121  YGFPQPRLPR FTNDPYPLFV TWKTGRDKRL RGCIGTFSAM NLHSGLREYT LTSALKDSRF
   181  PPLTREELPK LFCSVSLLTN FEDASDYLDW EVGVHGIRIE FINEKGVKRT ATYLPEVAKE
   241  QDWDQIQTID SLLRKGGFKA PITSEFRKTI KLTRYRSEKV TISYAEYIAS RQHCFQNGTL
   301  HAPPLYNHYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMMECR1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

pancreas: 11 nTPM
testis: 9 nTPM
parathyroid gland: 8.1 nTPM
urinary bladder: 7.8 nTPM
tongue: 7.6 nTPM
placenta: 7.2 nTPM

Single-cell type

endometrial stromal cells: 53 nCPM
melanocytes: 32 nCPM
adipocytes: 31 nCPM
ocular epithelial cells: 29 nCPM
decidual stromal cells: 29 nCPM
breast hormone-responsive cells: 25 nCPM

Immune cell

eosinophil: 4.2 nTPM
MAIT T-cell: 2 nTPM
neutrophil: 1.9 nTPM
plasmacytoid DC: 1.8 nTPM
myeloid DC: 1.7 nTPM
gdT-cell: 1.6 nTPM

Brain region

hippocampal formation: 12 nTPM
cerebral cortex: 12 nTPM
hypothalamus: 8.1 nTPM
basal ganglia: 7.9 nTPM
thalamus: 6.2 nTPM
midbrain: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 2.47
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMMECR1L as an antibody target. Whether an autoantibody or antibody against AMMECR1L could matter depends on whether native AMMECR1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMMECR1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMMECR1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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