Seroatlas · Human Serome Atlas

AMIGO3

Amphoterin-induced protein 3

Also known as: AMGO3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WK7
Gene: AMIGO3
Ensembl: ENSG00000176020
Chromosome: 3
Canonical length: 504 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in brain development; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and positive regulation of synapse assembly. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q86WK7|AMIGO3
     1  MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP
    61  AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT
   121  LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL
   181  SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS
   241  AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC
   301  NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH
   361  HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP
   421  QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN
   481  PGGLQLKAGS ESASSIGSEG PMTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMIGO3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 4.3 nTPM
skin: 3.4 nTPM
liver: 3.2 nTPM
skeletal muscle: 3.2 nTPM
pancreas: 3 nTPM
testis: 2.2 nTPM

Single-cell type

goblet cells: 1.6 nCPM
neuroendocrine cells: 1.4 nCPM
epididymal principal cells: 1.2 nCPM
colonocytes: 0.9 nCPM
epididymal efferent duct ciliated cells: 0.8 nCPM
granulosa cells: 0.8 nCPM

Immune cell

plasmacytoid DC: 11 nTPM
NK-cell: 1 nTPM
memory CD8 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.6 nTPM
T-reg: 0.5 nTPM
memory B-cell: 0.4 nTPM

Brain region

cerebellum: 6.9 nTPM
medulla oblongata: 5.5 nTPM
cerebral cortex: 5.2 nTPM
hypothalamus: 5.2 nTPM
amygdala: 4.7 nTPM
white matter: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-containing complex binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMIGO3 as an antibody target. Whether an autoantibody or antibody against AMIGO3 could matter depends on whether native AMIGO3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMIGO3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMIGO3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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