Seroatlas · Human Serome Atlas

AMIGO2

Amphoterin-induced protein 2

Also known as: ALI1, AMGO2_HUMAN, DEGA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86SJ2
Gene
AMIGO2
Ensembl
ENSG00000139211
Chromosome
12
Canonical length
522 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be active in membrane. Biomarker of gastric adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q86SJ2|AMIGO2
     1  MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD IVSCTNKNLS
    61  KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL RHNNITSIST GSFSTTPNLK
   121  CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN NHISYLDPSA FGGLSQLQKL YLSGNFLTQF
   181  PMDLYVGRFK LAELMFLDVS YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL
   241  VFWYRRHFSS VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA
   301  QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI ESPRFEDAGV
   361  YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF TTLAACVASI VLVLLYLYLT
   421  PCPCKCKTKR QKNMLHQSNA HSSILSPGPA SDASADERKA GAGKRVVFLE PLKDTAAGQN
   481  GKVRLFPSEA VIAEGILKST RGKSDSDSVN SVFSDTPFVA ST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMIGO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 68 nTPM
  • colon: 33 nTPM
  • smooth muscle: 32 nTPM
  • fallopian tube: 31 nTPM
  • endometrium: 24 nTPM
  • ovary: 24 nTPM

Single-cell type

  • breast myoepithelial cells: 109 nCPM
  • platelets: 96 nCPM
  • epididymal basal cells: 92 nCPM
  • endometrial glandular cells: 86 nCPM
  • urothelial cells: 74 nCPM
  • smooth muscle cells: 60 nCPM

Immune cell

  • naive CD4 T-cell: 15 nTPM
  • naive CD8 T-cell: 12 nTPM
  • plasmacytoid DC: 8.8 nTPM
  • NK-cell: 8.6 nTPM
  • memory CD8 T-cell: 6.9 nTPM
  • memory CD4 T-cell: 6.8 nTPM

Brain region

  • midbrain: 75 nTPM
  • pons: 40 nTPM
  • hypothalamus: 25 nTPM
  • medulla oblongata: 18 nTPM
  • cerebral cortex: 12 nTPM
  • basal ganglia: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.6
gnomAD missense Z
0.98
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AMIGO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMIGO2 as an antibody target. Whether an autoantibody or antibody against AMIGO2 could matter depends on whether native AMIGO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMIGO2 is annotated at the cell surface, where native AMIGO2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AMIGO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMIGO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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