Seroatlas · Human Serome Atlas

AMIGO1

Amphoterin-induced protein 1

Also known as: AMGO1_HUMAN, AMIGO, KIAA1163

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WK6
Gene
AMIGO1
Ensembl
ENSG00000181754
Chromosome
1
Canonical length
493 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable potassium channel regulator activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and positive regulation of nervous system development. Predicted to be located in dendrite; neuronal cell body membrane; and voltage-gated potassium channel complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q86WK6|AMIGO1
     1  MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP
    61  SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN
   121  QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE
   181  GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ
   241  LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV
   301  WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN
   361  FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS
   421  TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE
   481  SVSSVFSDTP IVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMIGO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • retina: 22 nTPM
  • cerebellum: 20 nTPM
  • cerebral cortex: 19 nTPM
  • skeletal muscle: 18 nTPM
  • basal ganglia: 13 nTPM
  • hypothalamus: 12 nTPM

Single-cell type

  • retinal bipolar cells: 22 nCPM
  • retinal amacrine cells: 16 nCPM
  • brain inhibitory neurons: 14 nCPM
  • oocytes: 14 nCPM
  • retinal pigment epithelial cells: 13 nCPM
  • other brain neurons: 12 nCPM

Immune cell

  • naive CD4 T-cell: 2.3 nTPM
  • naive CD8 T-cell: 1.7 nTPM
  • memory CD8 T-cell: 1.1 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • NK-cell: 0.9 nTPM
  • MAIT T-cell: 0.7 nTPM

Brain region

  • cerebral cortex: 47 nTPM
  • basal ganglia: 34 nTPM
  • hypothalamus: 32 nTPM
  • pons: 32 nTPM
  • thalamus: 32 nTPM
  • hippocampal formation: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.98
gnomAD missense Z
2.86
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AMIGO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMIGO1 as an antibody target. Whether an autoantibody or antibody against AMIGO1 could matter depends on whether native AMIGO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMIGO1 is annotated at the cell surface, where native AMIGO1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AMIGO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMIGO1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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