Seroatlas · Human Serome Atlas

AMER3

APC membrane recruitment protein 3

Also known as: AMER3_HUMAN, FAM123C, FLJ38377

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N944
Gene: AMER3
Ensembl: ENSG00000178171
Chromosome: 2
Canonical length: 861 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

861 residues, UniProt reviewed canonical sequence.

>Q8N944|AMER3
     1  MELKRGKTFI KSSLQVSHEK PPDPAAVAAA REGTGPWSVL PGGQQRPHSE KGPQASPSAQ
    61  EYDRCPNKGA QLDPKGGPAA LCGATFKPVR KCKTHDSMSG AGRATAATGQ LVGSASFPGS
   121  PGSRRMIDYR HFVPQMPFVP AVAKSIPRKR ISLKRPKKCF RNLFHIRRNK TEDLASLAAE
   181  GKSLPSPGDP SDPGGRRSKA FLPPGEGPGL DGLCQDLLDS ELLADASFGL CRALCEDVAS
   241  LQSFDSLTGC GEVFADESSV PSLELNEGPE SPTQAAQGLE SKVPRGPLQG SVEQLASPAQ
   301  NEASDFTRFW DSVNRSVRQQ QRALLGPWLS GPQGTDRDQS RLDTAGLAEL PLCPCRDPRS
   361  GSKASSIDTG TPKSEQPESV STSDEGYYDS FSPGLEEDKK EAESPGTPAA TFPRDSYSGD
   421  ALYELFHDPS EGPLGPSPDD DLCVSESLSG PALGTPLSIC SFRVGAEENL APAPGPDLLS
   481  QGFLQSSWKG KECLLKLCDT ELAITMGIVS WLRRGPTPRA PPTPGQPAAP PGSQGAPRAP
   541  TEKLGGREGL ASDAGGATVC SAPSRQELWA HPGTTGLLAG ESKALGGATQ GTGTLSRDAS
   601  REEETRGHSE GLFSSMESAA TSTTDTSGKN KAPVPSTWPC SQKEPGPPGV LGCFRGPWRP
   661  GHGGDTLDAE PMLAGCVARV AALKISSNEQ PPAAWPPRQD MGSGLFGQRW ARGPDMLEQK
   721  QSSSSPSMTT IHGLPYSAST QDQRCRDRVQ DLSWLRVEPT GLGVQAWASV EDQPLQLSTE
   781  AVEQVAHGSQ LDSEPRSAPA ARWSSQGHHP ESLGLTLNSQ QEGGVSASAP ECRCSLLARE
   841  GLLCGQPEVG ASGPAMAEPH L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.1 nTPM
cerebral cortex: 3.8 nTPM
retina: 2 nTPM
pancreas: 0.8 nTPM
basal ganglia: 0.6 nTPM
adrenal gland: 0.5 nTPM

Single-cell type

neuroendocrine cells: 15 nCPM
brain excitatory neurons: 14 nCPM
pancreatic islet cells: 11 nCPM
other brain neurons: 11 nCPM
adrenal medulla cells: 11 nCPM
brain inhibitory neurons: 9.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 38 nTPM
cerebral cortex: 32 nTPM
basal ganglia: 22 nTPM
white matter: 21 nTPM
hypothalamus: 21 nTPM
amygdala: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AMER3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 161 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Esophageal atresia/tracheoesophageal fistula

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.62
gnomAD missense Z: -0.67
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMER3 as an antibody target. Whether an autoantibody or antibody against AMER3 could matter depends on whether native AMER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMER3 is annotated at the cell surface, where native AMER3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AMER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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