AMER2

Protein identityUniProt · HPA

UniProt accession

Q8N7J2

Gene

AMER2

Ensembl

ENSG00000165566

Chromosome

13

Canonical length

671 aa

Protein class

Predicted intracellular proteins

Subcellular location

Plasma membrane

OverviewNCBI Gene

Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q8N7J2|AMER2
     1  METSRSRGGG GAVSERGGAG ASVGVCRRKA EAGAGTGTLA ADMDLHCDCA AETPAAEPPS
    61  GKINKAAFKL FKKRKSGGTM PSIFGVKNKG DGKSSGPTGL VRSRTHDGLA EVLVLESGRK
   121  EEPRGGGDSG GGGGGRPNPG PPRAAGPGGG SLASSSVAKS HSFFSLLKKN GRSENGKGEP
   181  VDASKAGGKQ KRGLRGLFSG MRWHRKDKRA KAEAAEGRAP GGGLILPGSL TASLECVKEE
   241  TPRAAREPEE PSQDAPRDPA GEPAGGEEVP APADRAPARS CREAEGLAHP GDTGARGEDA
   301  AGHRRAEPGP GEVRTAEDAS RTGAVPVKTV PLVDSEGGSG RAPAAPDPAS VDPPSDPSAD
   361  RICLMFSDVT SLKSFDSLTG CGDIIADQEE EAGPSCDKHV PGPGKPALSK KNPGVVAYQG
   421  GGEEMASPDE VDDTYLQEFW DMLSQTEEQG PEPQEGAAKV AAALETKVVP ETPKDTRCVE
   481  AAKDASSVKR RRLNRIPIEP HPKEEPKHPE KEQQEGVPNS DEGYWDSTTP GPEEDSSSSG
   541  KKAGIPRDSY SGDALYDLYA DPDGSPATLP GGKDNEETSS LSRLKPVSPG TITCPLRTPG
   601  SLLKDSKIPI SIKHLTNLPS SHPVVHQQPS RSEMPRTKIP VSKVLVRRVS NRGLAGTTIR
   661  ATACHDSAKK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.73

Highest tissue expression

35 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0.08

gnomAD missense Z

1.17

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ectoderm development
• negative regulation of canonical Wnt signaling pathway
• regulation of canonical Wnt signaling pathway
• Wnt signaling pathway

Molecular functions

• beta-catenin binding
• phosphatidylinositol-4,5-bisphosphate binding

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• APC membrane recruitment protein
• APC membrane recruitment protein

KeywordsUniProt

• Cell membrane
• Lipid-binding
• Membrane
• Phosphoprotein
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of AMER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APC