AMELY
Amelogenin, Y isoform
Also known as: AMELY_HUMAN, AMGL
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99218
- Gene
- AMELY
- Ensembl
- ENSG00000099721
- Chromosome
- Y
- Canonical length
- 206 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
206 residues, UniProt reviewed canonical sequence.
>Q99218|AMELY
1 MGTWILFACL VGAAFAMPLP PHPGHPGYIN FSYENSHSQA INVDRIALVL TPLKWYQSMI
61 RPPYSSYGYE PMGGWLHHQI IPVVSQQHPL THTLQSHHHI PVVPAQQPRV RQQALMPVPG
121 QQSMTPTQHH QPNLPLPAQQ PFQPQPVQPQ PHQPMQPQPP VQPMQPLLPQ PPLPPMFPLR
181 PLPPILPDLH LEAWPATDKT KQEEVDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against AMELY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 0.2 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 0.2 nTPM
- kidney: 0.1 nTPM
- pancreas: 0.1 nTPM
- prostate: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- cytotrophoblasts: 2.3 nCPM
- parietal cells: 1.8 nCPM
- undifferentiated spermatogonia: 1.7 nCPM
- ependymal cells: 1.1 nCPM
- gastric chief cells: 1.1 nCPM
- adipocytes: 0.9 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.13
- DepMap mean gene effect
- 0.21
- DepMap dependency class
- none
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads AMELY as an antibody target. Whether an autoantibody or antibody against AMELY could matter depends on whether native AMELY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
AMELY is annotated as secreted, so native AMELY circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label AMELY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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