Seroatlas · Human Serome Atlas

AMD1

S-adenosylmethionine decarboxylase proenzyme

Also known as: DCAM_HUMAN, SAMDC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17707
Gene
AMD1
Ensembl
ENSG00000123505
Chromosome
6
Canonical length
334 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>P17707|AMD1
     1  MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ
    61  EAYVLSESSM FVSKRRFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP
   121  SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL
   181  MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW
   241  TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ
   301  KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AMD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
190 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 190 nTPM
  • bone marrow: 85 nTPM
  • spinal cord: 59 nTPM
  • placenta: 56 nTPM
  • esophagus: 53 nTPM
  • tonsil: 47 nTPM

Single-cell type

  • prostatic glandular cells: 1,121 nCPM
  • platelets: 629 nCPM
  • megakaryocyte-erythroid progenitors: 547 nCPM
  • megakaryocyte progenitors: 422 nCPM
  • hematopoietic stem cells: 389 nCPM
  • erythrocyte progenitors: 380 nCPM

Immune cell

  • neutrophil: 103 nTPM
  • basophil: 43 nTPM
  • eosinophil: 38 nTPM
  • non-classical monocyte: 38 nTPM
  • myeloid DC: 32 nTPM
  • intermediate monocyte: 29 nTPM

Brain region

  • white matter: 107 nTPM
  • medulla oblongata: 65 nTPM
  • spinal cord: 65 nTPM
  • basal ganglia: 62 nTPM
  • cerebral cortex: 59 nTPM
  • pons: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
2.24
DepMap mean gene effect
-0.48
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • S-adenosylmethionine decarboxylase, eukaryotes
  • S-adenosylmethionine decarboxylase, core
  • S-adenosylmethionine decarboxylase, conserved site
  • S-adenosylmethionine decarboxylase-like
  • Adenosylmethionine decarboxylase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AMD1 as an antibody target. Whether an autoantibody or antibody against AMD1 could matter depends on whether native AMD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AMD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AMD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AMD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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