Seroatlas · Human Serome Atlas

ALG1L2

Putative glycosyltransferase ALG1L2

Also known as: AG1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9J202
Gene: ALG1L2
Ensembl: ENSG00000251287
Chromosome: 3
Canonical length: 215 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>C9J202|ALG1L2
     1  MGATAGWAVT VYDKPASFFK EAPLDLQHRL FMKLGSTHSP FRARSEPEDP DTERSAFTER
    61  DSGSGLVTRL HERPALLVSS TSWTEFEQLT LDGQNLPSLV CVITGKGPLR EYYSRLIHQK
   121  HFQHIQVCIP WLEGRGLPPL LGSVDLDVCL DTSSSGLDLP MKVVDMFRCC LPACAVNFKC
   181  LHELVKHEEN RLVFEDSEEL AAQLQYFADA FLKLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALG1L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

retina: 2.4 nTPM
spleen: 0.7 nTPM
appendix: 0.2 nTPM
bone marrow: 0.2 nTPM
skin: 0.2 nTPM
duodenum: 0.1 nTPM

Single-cell type

epicardial cells: 39 nCPM
tuft cells: 23 nCPM
cardiomyocytes: 19 nCPM
paneth cells: 16 nCPM
hematopoietic stem cells: 15 nCPM
pdcs: 13 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
T-reg: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

hypothalamus: 6.4 nTPM
white matter: 5 nTPM
cerebral cortex: 4.9 nTPM
basal ganglia: 4.3 nTPM
thalamus: 4.2 nTPM
pons: 4 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mannosyltransferase activity

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALG1L2 as an antibody target. Whether an autoantibody or antibody against ALG1L2 could matter depends on whether native ALG1L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALG1L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALG1L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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