Seroatlas · Human Serome Atlas

ALDOC

Fructose-bisphosphate aldolase C

Also known as: ALDOC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09972
Gene: ALDOC
Ensembl: ENSG00000109107
Chromosome: 17
Canonical length: 364 aa
Protein class: Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>P09972|ALDOC
     1  MPHSYPALSA EQKKELSDIA LRIVAPGKGI LAADESVGSM AKRLSQIGVE NTEENRRLYR
    61  QVLFSADDRV KKCIGGVIFF HETLYQKDDN GVPFVRTIQD KGIVVGIKVD KGVVPLAGTD
   121  GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKISERTPS ALAILENANV LARYASICQQ
   181  NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HVYLEGTLLK PNMVTPGHAC
   241  PIKYTPEEIA MATVTALRRT VPPAVPGVTF LSGGQSEEEA SFNLNAINRC PLPRPWALTF
   301  SYGRALQASA LNAWRGQRDN AGAATEEFIK RAEVNGLAAQ GKYEGSGEDG GAAAQSLYIA
   361  NHAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 1,156 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 1,156 nTPM
retina: 1,098 nTPM
amygdala: 1,056 nTPM
cerebellum: 1,048 nTPM
basal ganglia: 987 nTPM
midbrain: 806 nTPM

Single-cell type

astrocytes: 106 nCPM
bergmann glia: 88 nCPM
oligodendrocyte progenitor cells: 46 nCPM
other brain neurons: 45 nCPM
brain inhibitory neurons: 39 nCPM
brain excitatory neurons: 34 nCPM

Immune cell

T-reg: 41 nTPM
naive CD4 T-cell: 38 nTPM
MAIT T-cell: 31 nTPM
memory CD4 T-cell: 30 nTPM
NK-cell: 30 nTPM
naive CD8 T-cell: 29 nTPM

Brain region

pons: 1,735 nTPM
cerebellum: 1,428 nTPM
medulla oblongata: 1,347 nTPM
cerebral cortex: 1,250 nTPM
thalamus: 1,159 nTPM
midbrain: 860 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ALDOC.

Disease | ImmuneIEDB

Conditions an epitope on ALDOC was assayed in.

multiple sclerosis B cell
onchocerciasis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.09
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALDOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDOC as an antibody target. Whether an autoantibody or antibody against ALDOC could matter depends on whether native ALDOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDOC is annotated as secreted, so native ALDOC circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ALDOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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