Seroatlas · Human Serome Atlas

AKR7L

Aflatoxin B1 aldehyde reductase member 4

Also known as: ARK74_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHP1
Gene: AKR7L
Canonical length: 331 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for AKR7L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q8NHP1|AKR7L
     1  MSRQLSRARP ATVLGAMEMG RRMDAPTSAA VTRAFLERGH TEIDTAFLYS DGQSETILGG
    61  LGLRMGSSDC RVKIATKANP WIGNSLKPDS VRSQLETSLK RLQCPRVDLF YLHAPDHSAP
   121  VEETLRACHQ LHQEGKFVEL GLSNYAAWEV AEICTLCKSN GWILPTVYQG MYSATTRQVE
   181  TELFPCLRHF GLRFYAYNPL AGGLLTGKYK YEDKDGKQPV GRFFGTQWAE IYRNHFWKEH
   241  HFEGIALVEK ALQAAYGASA PSMTSAALRW MYHHSQLQGA HGDAVILGMS SLEQLEQNLA
   301  AAEEGPLEPA VVDAFNQAWH LFAHECPNYF I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

duodenum: 58 nTPM
small intestine: 45 nTPM
liver: 35 nTPM
stomach: 24 nTPM
kidney: 7.6 nTPM
colon: 4.9 nTPM

Single-cell type

enterocytes: 60 nCPM
foveolar cells: 19 nCPM
hepatocytes: 17 nCPM
mucous neck cells: 14 nCPM
enteric transient amplifying cells: 7.8 nCPM
pancreatic acinar cells: 7.8 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

choroid plexus: 10 nTPM
cerebellum: 9.8 nTPM
cerebral cortex: 7 nTPM
hippocampal formation: 6.9 nTPM
amygdala: 6.5 nTPM
basal ganglia: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.26

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKR7L as an antibody target. Whether an autoantibody or antibody against AKR7L could matter depends on whether native AKR7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKR7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKR7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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