Seroatlas · Human Serome Atlas

AKR1E2

1,5-anhydro-D-fructose reductase

Also known as: AKCL2_HUMAN, AKR1CL2, AKRDC1, htAKR, HTSP1, MGC10612

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JD6
Gene
AKR1E2
Ensembl
ENSG00000165568
Chromosome
10
Canonical length
320 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q96JD6|AKR1E2
     1  MGDIPAVGLS SWKASPGKVT EAVKEAIDAG YRHFDCAYFY HNEREVGAGI RCKIKEGAVR
    61  REDLFIATKL WCTCHKKSLV ETACRKSLKA LKLNYLDLYL IHWPMGFKPP HPEWIMSCSE
   121  LSFCLSHPRV QDLPLDESNM VIPSDTDFLD TWEAMEDLVI TGLVKNIGVS NFNHEQLERL
   181  LNKPGLRFKP LTNQIECHPY LTQKNLISFC QSRDVSVTAY RPLGGSCEGV DLIDNPVIKR
   241  IAKEHGKSPA QILIRFQIQR NVIVIPGSIT PSHIKENIQV FDFELTQHDM DNILSLNRNL
   301  RLAMFPITKN HKDYPFHIEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR1E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • retina: 3.1 nTPM
  • thyroid gland: 3.1 nTPM
  • breast: 2.8 nTPM
  • bone marrow: 2 nTPM
  • pancreas: 2 nTPM

Single-cell type

  • late spermatids: 258 nCPM
  • early spermatids: 228 nCPM
  • late primary spermatocytes: 102 nCPM
  • early primary spermatocytes: 79 nCPM
  • retinal horizontal cells: 54 nCPM
  • retinal ganglion cells: 50 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • myeloid DC: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • naive CD4 T-cell: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 12 nTPM
  • hypothalamus: 11 nTPM
  • pons: 11 nTPM
  • cerebral cortex: 10 nTPM
  • midbrain: 10 nTPM
  • thalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.42
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKR1E2 as an antibody target. Whether an autoantibody or antibody against AKR1E2 could matter depends on whether native AKR1E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKR1E2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKR1E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKR1E2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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