Seroatlas · Human Serome Atlas

AKR1C4

Aldo-keto reductase family 1 member C4

Also known as: 3-alpha-HSD, AK1C4_HUMAN, C11, CDR, CHDR, DD4, HAKRA, MGC22581

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17516
Gene
AKR1C4
Ensembl
ENSG00000198610
Chromosome
10
Canonical length
323 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P17516|AKR1C4
     1  MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ
    61  VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM
   121  ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP
   181  GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV
   241  LCALAKKHKQ TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN
   301  RNYRYVVMDF LMDHPDYPFS DEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR1C4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
670 nTPM

Expression across tissuesHPA

Tissue

  • liver: 670 nTPM
  • gallbladder: 39 nTPM
  • duodenum: 2.3 nTPM
  • small intestine: 1.1 nTPM
  • stomach: 1.1 nTPM
  • testis: 0.7 nTPM

Single-cell type

  • hepatocytes: 808 nCPM
  • cholangiocytes: 29 nCPM
  • kupffer cells: 9.2 nCPM
  • late primary spermatocytes: 7.4 nCPM
  • early spermatids: 6.2 nCPM
  • epicardial cells: 4.5 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.4 nTPM
  • medulla oblongata: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • pons: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • white matter: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AKR1C4.

Disease | AllUniProt

Conditions AKR1C4 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
-1.04
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKR1C4 as an antibody target. Whether an autoantibody or antibody against AKR1C4 could matter depends on whether native AKR1C4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKR1C4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKR1C4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKR1C4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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