AKR1C3

Protein identityUniProt · HPA

UniProt accession

P42330

Gene

AKR1C3

Ensembl

ENSG00000196139

Chromosome

10

Canonical length

323 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli fibrillar center,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P42330|AKR1C3
     1  MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ
    61  VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM
   121  SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP
   181  GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV
   241  LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD
   301  RNLHYFNSDS FASHPNYPYS DEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR1C3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

415 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AKR1C3.

Disease | ImmuneIEDB

Conditions an epitope on AKR1C3 was assayed in.

• cholangiocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.86

gnomAD pLI

0

gnomAD missense Z

-1.81

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to calcium ion
• cellular response to jasmonic acid stimulus
• cellular response to prostaglandin D stimulus
• cellular response to starvation
• daunorubicin metabolic process
• doxorubicin metabolic process
• farnesol catabolic process
• G protein-coupled receptor signaling pathway
• keratinocyte differentiation
• male gonad development
• negative regulation of retinoic acid biosynthetic process
• positive regulation of cell population proliferation
• positive regulation of endothelial cell apoptotic process
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of reactive oxygen species metabolic process
• progesterone metabolic process
• prostaglandin metabolic process
• prostanoid biosynthetic process
• regulation of retinoic acid receptor signaling pathway
• regulation of testosterone biosynthetic process
• renal absorption
• response to nutrient
• retinal metabolic process
• retinoid metabolic process
• steroid metabolic process
• testosterone biosynthetic process
• cellular response to corticosteroid stimulus
• cellular response to prostaglandin stimulus
• macromolecule metabolic process

Molecular functions

• 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
• 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity
• 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
• alcohol dehydrogenase (NADP+) activity
• aldose reductase (NADPH) activity
• all-trans-retinol dehydrogenase (NAD+) activity
• all-trans-retinol dehydrogenase (NADP+) activity
• androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
• androsterone dehydrogenase [NAD(P)+] activity
• bile acid binding
• Delta4-3-oxosteroid 5beta-reductase activity
• estradiol 17-beta-dehydrogenase [NAD(P)+] activity
• geranylgeranyl reductase activity
• ketosteroid monooxygenase activity
• oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
• prostaglandin F synthase activity
• prostaglandin H2 endoperoxidase reductase activity
• retinal dehydrogenase (NAD+) activity
• testosterone dehydrogenase (NAD+) activity
• testosterone dehydrogenase (NADP+) activity
• ketoreductase activity
• prostaglandin D2 11-ketoreductase activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Aldo/keto reductase, conserved site
• Aldo-keto reductase
• NADP-dependent oxidoreductase domain
• NAD(P)-dependent oxidoreductase domain superfamily
• Aldo-keto reductase family 1 member C
• Aldo/keto reductase family

KeywordsUniProt

• Cytoplasm
• Lipid metabolism
• NAD
• NADP
• Oxidoreductase

InteractionsUniProt · HPA

Protein binding partners of AKR1C3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AKR1C2