Seroatlas · Human Serome Atlas

AKR1B10

Aldo-keto reductase family 1 member B10

Also known as: AK1BA_HUMAN, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60218
Gene
AKR1B10
Ensembl
ENSG00000198074
Chromosome
7
Canonical length
316 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>O60218|AKR1B10
     1  MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ
    61  EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD
   121  DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP
   181  VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK
   241  HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN
   301  VLQSSHLEDY PFNAEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR1B10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
578 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 578 nTPM
  • stomach: 408 nTPM
  • small intestine: 334 nTPM
  • esophagus: 211 nTPM
  • gallbladder: 166 nTPM
  • vagina: 137 nTPM

Single-cell type

  • esophageal suprabasal cells: 880 nCPM
  • foveolar cells: 853 nCPM
  • esophageal basal cells: 569 nCPM
  • suprabasal keratinocytes: 497 nCPM
  • enterocytes: 304 nCPM
  • basal keratinocytes: 226 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.5 nTPM
  • pons: 1.2 nTPM
  • cerebral cortex: 1.1 nTPM
  • hippocampal formation: 1.1 nTPM
  • spinal cord: 1.1 nTPM
  • white matter: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0
gnomAD missense Z
-0.19
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKR1B10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKR1B10 as an antibody target. Whether an autoantibody or antibody against AKR1B10 could matter depends on whether native AKR1B10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKR1B10 is annotated as secreted, so native AKR1B10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AKR1B10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKR1B10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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