Seroatlas · Human Serome Atlas

AKR1A1

Aldo-keto reductase family 1 member A1

Also known as: AK1A1_HUMAN, ALR, DD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14550
Gene
AKR1A1
Ensembl
ENSG00000117448
Chromosome
1
Canonical length
325 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P14550|AKR1A1
     1  MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL
    61  KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER
   121  GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP
   181  AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEK
   241  YGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV
   301  PMLTVDGKRV PRDAGHPLYP FNDPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKR1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
302 nTPM

Expression across tissuesHPA

Tissue

  • liver: 302 nTPM
  • kidney: 302 nTPM
  • duodenum: 178 nTPM
  • small intestine: 162 nTPM
  • pancreas: 135 nTPM
  • esophagus: 133 nTPM

Single-cell type

  • enterocytes: 812 nCPM
  • breast lactating cells: 609 nCPM
  • hofbauer cells: 567 nCPM
  • esophageal apical cells: 400 nCPM
  • esophageal suprabasal cells: 399 nCPM
  • respiratory secretory cells: 324 nCPM

Immune cell

  • classical monocyte: 230 nTPM
  • intermediate monocyte: 225 nTPM
  • myeloid DC: 197 nTPM
  • total PBMC: 183 nTPM
  • non-classical monocyte: 175 nTPM
  • plasmacytoid DC: 170 nTPM

Brain region

  • white matter: 63 nTPM
  • choroid plexus: 54 nTPM
  • thalamus: 46 nTPM
  • medulla oblongata: 45 nTPM
  • spinal cord: 42 nTPM
  • pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.02
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKR1A1 as an antibody target. Whether an autoantibody or antibody against AKR1A1 could matter depends on whether native AKR1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKR1A1 is annotated at the cell surface, where native AKR1A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AKR1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKR1A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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