Seroatlas · Human Serome Atlas

AKNAD1

Protein AKNAD1

Also known as: AKND1_HUMAN, C1orf62, MGC26989

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T1N1
Gene: AKNAD1
Ensembl: ENSG00000162641
Chromosome: 1
Canonical length: 836 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

This gene encodes a protein which contains a domain found in an AT-hook-containing transcription factor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q5T1N1|AKNAD1
     1  MDEADFSEHT TYKQEDLPYD GDLSQIKIGN DYSFTSKKDG LEVLNQIIFI ADDPQEKAMH
    61  SETCGNTAVT IPLGKITENA ANKKDEKEKQ CTAALHIPAN EGDASKSSIS DILLHHLSKE
   121  PFLRGQGIDC ETLPEISNAD SFEEEAIIKS IISCYNKNSW PKEQTPELTD QLNPKRDGEN
   181  SNKPGSATTT EENTSDLEGP VAAGDSSHQE NVNVLTKTKG PGDKQKSYQG QSPQKQQTEK
   241  ANSGNTFKYG QGQVHYQLPD FSKIAPKVKI PKNKIINKPL AIAKQASFSS KSRDKPTLVQ
   301  DSLETTPESN CVEKQHQEQK GKITEPSQQI QMEPIVHIHQ ELLTGIESEA SLSKLSPTSQ
   361  KGTSSSSSYI FQKISQGKQM CQKLKEQTDQ LKTKVQEFSK RIKQDSPYHL QDKKLVLEKL
   421  QGHLELLEQN FLATKDKHLT LQQQVHKHES TIVGDFDPER KVEGEIFKLE MLLEDVKEKM
   481  DESKYTSAPS LPVSSPVTLD DLASTFSSLS NEIPKEHPGH PSGPRGSGGS EVTGTPQGGP
   541  QEAPNEELCE LAPQTYLNGH YGDAAAQNKP DQVAMRLSSN SGEDPNGTPR RQDCAEMTAP
   601  SPSCAFCRRL LEWKQNVEKK GHGRINCGRF SIVLHEKAPH SDSTPNSDTG HSFCSDSGTE
   661  MQSNKCQDCG TKIPTSRRAC RKEPTKEFHY RYNTPGQNYS NHSKRGAFVQ PHSLDESKNS
   721  SPSFLKPKRI CSQRVNSKSF KGEHEPTPGK KKLQAFMTYS SDPATPSPHF YSCRISGSKS
   781  LCDFDSTEEI KSEILNSALD HALRTATILK ETTDQMIKTI AEDLAKAQRW RNRLKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKNAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

testis: 4.6 nTPM
thymus: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 225 nCPM
late primary spermatocytes: 71 nCPM
bergmann glia: 62 nCPM
oligodendrocyte progenitor cells: 52 nCPM
oligodendrocytes: 50 nCPM
astrocytes: 37 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.4 nTPM
medulla oblongata: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
hypothalamus: 0.2 nTPM
pons: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKNAD1 as an antibody target. Whether an autoantibody or antibody against AKNAD1 could matter depends on whether native AKNAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKNAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKNAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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