Seroatlas · Human Serome Atlas

AKAP14

A-kinase anchor protein 14

Also known as: AKA28_HUMAN, AKAP28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UN6
Gene: AKAP14
Ensembl: ENSG00000186471
Chromosome: X
Canonical length: 197 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q86UN6|AKAP14
     1  MSETQNSTSQ KAMDEDNKAA SQTMPNTQDK NYEDELTQVA LALVEDVINY AVKIVEEERN
    61  PLKNIKWMTH GEFTVEKGLK QIDEYFSKCV SKKCWAHGVE FVERKDLIHS FLYIYYVHWS
   121  ISTADLPVAR ISAGTYFTMK VSKTKPPDAP IVVSYVGDHQ ALVHRPGMVR FRENWQKNLT
   181  DAKYSFMESF PFLFNRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

testis: 82 nTPM
choroid plexus: 73 nTPM
fallopian tube: 41 nTPM
hypothalamus: 5 nTPM
amygdala: 4.2 nTPM
lung: 3.2 nTPM

Single-cell type

late spermatids: 2,646 nCPM
early spermatids: 551 nCPM
fallopian tube ciliated cells: 261 nCPM
respiratory ciliated cells: 246 nCPM
endometrial ciliated cells: 147 nCPM
late primary spermatocytes: 142 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 34 nTPM
midbrain: 7.5 nTPM
hypothalamus: 7.1 nTPM
medulla oblongata: 7 nTPM
pons: 2.8 nTPM
hippocampal formation: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.66
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein kinase A regulatory subunit binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

A-kinase anchor protein 28kDa
A-kinase anchor protein
28 kDa A-kinase anchor

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of AKAP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAP14 as an antibody target. Whether an autoantibody or antibody against AKAP14 could matter depends on whether native AKAP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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