Seroatlas · Human Serome Atlas

AKAP10

A-kinase anchor protein 10, mitochondrial

Also known as: AKA10_HUMAN, D-AKAP2, MGC9414, PRKA10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43572
Gene: AKAP10
Ensembl: ENSG00000108599
Chromosome: 17
Canonical length: 662 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>O43572|AKAP10
     1  MRGAGPSPRQ SPRTLRPDPG PAMSFFRRKV KGKEQEKTSD VKSIKASISV HSPQKSTKNH
    61  ALLEAAGPSH VAINAISANM DSFSSSRTAT LKKQPSHMEA AHFGDLGRSC LDYQTQETKS
   121  SLSKTLEQVL HDTIVLPYFI QFMELRRMEH LVKFWLEAES FHSTTWSRIR AHSLNTVKQS
   181  SLAEPVSPSK KHETTASFLT DSLDKRLEDS GSAQLFMTHS EGIDLNNRTN STQNHLLLSQ
   241  ECDSAHSLRL EMARAGTHQV SMETQESSST LTVASRNSPA SPLKELSGKL MKSIEQDAVN
   301  TFTKYISPDA AKPIPITEAM RNDIIARICG EDGQVDPNCF VLAQSIVFSA MEQEHFSEFL
   361  RSHHFCKYQI EVLTSGTVYL ADILFCESAL FYFSEYMEKE DAVNILQFWL AADNFQSQLA
   421  AKKGQYDGQE AQNDAMILYD KYFSLQATHP LGFDDVVRLE IESNICREGG PLPNCFTTPL
   481  RQAWTTMEKV FLPGFLSSNL YYKYLNDLIH SVRGDEFLGG NVSLTAPGSV GPPDESHPGS
   541  SDSSASQSSV KKASIKILKN FDEAIIVDAA SLDPESLYQR TYAGKMTFGR VSDLGQFIRE
   601  SEPEPDVRKS KGSMFSQAMK KWVQGNTDEA QEELAWKIAK MIVSDIMQQA QYDQPLEKST
   661  KL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

lymph node: 15 nTPM
parathyroid gland: 14 nTPM
retina: 14 nTPM
spleen: 14 nTPM
thyroid gland: 14 nTPM
testis: 13 nTPM

Single-cell type

neutrophils: 253 nCPM
neutrophil progenitors: 210 nCPM
microglia: 205 nCPM
adrenal cortex cells: 171 nCPM
choroid plexus epithelial cells: 162 nCPM
myonuclei: 147 nCPM

Immune cell

neutrophil: 34 nTPM
intermediate monocyte: 15 nTPM
non-classical monocyte: 14 nTPM
eosinophil: 13 nTPM
naive CD4 T-cell: 10 nTPM
classical monocyte: 9.7 nTPM

Brain region

choroid plexus: 40 nTPM
white matter: 37 nTPM
thalamus: 36 nTPM
cerebral cortex: 34 nTPM
hypothalamus: 32 nTPM
cerebellum: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.11
gnomAD missense Z: 1.35
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase A binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RGS domain
RGS domain superfamily
RGS, subdomain 2
Regulator of G protein signaling domain
A-kinase anchor protein 10, PKA-binding (AKB) domain
Cell Polarization and PKA Anchoring

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAP10 as an antibody target. Whether an autoantibody or antibody against AKAP10 could matter depends on whether native AKAP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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