Seroatlas · Human Serome Atlas

AKAIN1

A-kinase anchor protein inhibitor 1

Also known as: AKAI1_HUMAN, C18orf42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CW23
Gene: AKAIN1
Ensembl: ENSG00000231824
Chromosome: 18
Canonical length: 69 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables protein kinase A binding activity. Involved in protein localization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

69 residues, UniProt reviewed canonical sequence.

>P0CW23|AKAIN1
     1  MVFAPGEKPG NEPEEVKLQN ASKQIVQNAI LQAVQQVSQE SQRREERISD NRDHIQLGVG
    61  ELTKKHEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 41 nTPM
adrenal gland: 9.6 nTPM
hippocampal formation: 6.7 nTPM
retina: 4 nTPM
pituitary gland: 2.4 nTPM
cerebral cortex: 1.7 nTPM

Single-cell type

brain excitatory neurons: 29 nCPM
pancreatic islet cells: 19 nCPM
retinal bipolar cells: 8.1 nCPM
somatotrophs: 5.8 nCPM
brain inhibitory neurons: 5.5 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 51 nTPM
cerebral cortex: 37 nTPM
hippocampal formation: 25 nTPM
thalamus: 14 nTPM
medulla oblongata: 8.5 nTPM
pons: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.49
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase A binding

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAIN1 as an antibody target. Whether an autoantibody or antibody against AKAIN1 could matter depends on whether native AKAIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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