Seroatlas · Human Serome Atlas

AJM1

Apical junction component 1 homolog

Also known as: ajm-1, AJM1_HUMAN, C9orf172

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9J069
Gene: AJM1
Ensembl: ENSG00000232434
Chromosome: 9
Canonical length: 976 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in cell-cell junction organization. Predicted to be located in adherens junction; apical plasma membrane; and cilium. Predicted to be active in apical junction complex and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

976 residues, UniProt reviewed canonical sequence.

>C9J069|AJM1
     1  MTRTDPPDLL VSTVYQDIKV ATPGPASKCS PCERSVARPA EPAPFNKRHC RSFDFLEALD
    61  GPAMETLPEP PPPESAVPRA RTREAEPRRR ARSKSAPRAP PGLTPAPASP PVLPRRGREA
   121  QRAARAEASP RREPAYPALR ALANELHPIK LQPQRGGPGR VAPLCAAAGR CAPPEPPAGP
   181  APHVRCRLDI KPDDAVLQHA TRGSRSCGPT EAAHWARPAP QFHGLTVPGP RHMALSRTPT
   241  PSDSYCADPR AFYCDGPLPG PRDYAERRSL PFTTPPGPTQ FFYTEEPQGF RGSFAASPGP
   301  TFDAYYPRPY PSEELSGPSP RRMGGYYAGE VRTFPIQEPP SRSYYGEAPR AYGLPYGPRY
   361  VPEEPRAHST ARPFYTEDFG RYRERDVLAR TYPHPRSSPA WADWGPRPYR TLQVVPPSDP
   421  DPLLASWHGG TGTSPPRLAT DSRHYSRSWD NILAPGPRRE DPLGRGRSYE NLLGREVREP
   481  RGVSPEGRRP PVVVNLSTSP RRYAALSLSE TSLTEKGRAG EGLGRNWYVT PEITITDNDL
   541  RATERPSARA WELPGGRTRP PPHAAPDGPT SGRQRSLEQL DELITDLVID SRPTAGQASE
   601  PAADCLGPQL RRLLDSRPAG SGAPALAPPR SPPASAGSAE EPAAPGEAAD ASPEPSADED
   661  DLMTCSNARC RRTETMFNAC LYFKSCHSCY TYYCSRLCRR EDWDAHKARC VYGRVGSVCR
   721  HVLQFCRDSG PVHRAFSRIA RVGFLSRGRG VLFLGFPSPG SADNFLRFGL EGLLLSPTYL
   781  SLRELATHAA PLGSYARELA AAGRLYEPAE CFLLSVSVAV GPGTAPPGTP ALPAPAPRSH
   841  GPTVRKFAKV ALAAGSPARP PPARSREPDM ETLILTPPPG TAGLDQDGEA GRRAREVAFI
   901  HIQRELRLRG VFLRHEFPRV YEQLCEFVEA NRRFTPTTIY PTDRRTGRPF MCMIMAASEP
   961  RALDWVASAN LLDDIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AJM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 66 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 23 nTPM
hippocampal formation: 23 nTPM
amygdala: 21 nTPM
pituitary gland: 19 nTPM

Single-cell type

late spermatids: 40 nCPM
epididymal principal cells: 37 nCPM
ependymal cells: 18 nCPM
retinal bipolar cells: 18 nCPM
early spermatids: 17 nCPM
thyrotrophs: 16 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
non-classical monocyte: 0.5 nTPM
classical monocyte: 0.4 nTPM
gdT-cell: 0.4 nTPM
myeloid DC: 0.4 nTPM
intermediate monocyte: 0.3 nTPM

Brain region

cerebellum: 98 nTPM
hippocampal formation: 80 nTPM
cerebral cortex: 77 nTPM
basal ganglia: 75 nTPM
amygdala: 73 nTPM
white matter: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell-cell junction organization

Cellular components

Protein domainsUniProt · Pfam · InterPro

Apical junction component
Apical junction molecule ajm1, alpha/beta domain
Apical junction molecule ajm-1 alpha/beta domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AJM1 as an antibody target. Whether an autoantibody or antibody against AJM1 could matter depends on whether native AJM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AJM1 is annotated at the cell surface, where native AJM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AJM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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