Seroatlas · Human Serome Atlas

AIRIM

AFG2-interacting ribosome maturation factor

Also known as: AIRIM_HUMAN, C1orf109, FLJ20508

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX04
Gene: AIRIM
Ensembl: ENSG00000116922
Chromosome: 1
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q9NX04|AIRIM
     1  MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ AAQNLRFEDV
    61  PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD MVSSHVERVF QIYEQHADTV
   121  GIDAVLQPSA VSPSVADMLE WLQDIERHYR KSYLKRKYLL SSIQWGDLAN IQALPKAWDR
   181  ISKDEHQDLV QDILLNVSFF LEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIRIM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
pancreas: 12 nTPM
ovary: 11 nTPM
adrenal gland: 9.6 nTPM
lymph node: 9.3 nTPM
epididymis: 8.9 nTPM

Single-cell type

suprabasal keratinocytes: 45 nCPM
basal keratinocytes: 41 nCPM
early primary spermatocytes: 33 nCPM
erythrocyte progenitors: 30 nCPM
differentiating spermatogonia: 29 nCPM
pdcs: 24 nCPM

Immune cell

plasmacytoid DC: 47 nTPM
MAIT T-cell: 26 nTPM
naive CD4 T-cell: 26 nTPM
naive CD8 T-cell: 22 nTPM
NK-cell: 22 nTPM
memory CD4 T-cell: 20 nTPM

Brain region

thalamus: 13 nTPM
spinal cord: 10 nTPM
midbrain: 9.8 nTPM
white matter: 9.4 nTPM
cerebral cortex: 8.8 nTPM
amygdala: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
DepMap mean gene effect: -1.29
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosomal large subunit biogenesis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosome biogenesis protein C1orf109-like
Ribosome biogenesis protein C1orf109-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIRIM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CINP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIRIM as an antibody target. Whether an autoantibody or antibody against AIRIM could matter depends on whether native AIRIM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIRIM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIRIM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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