AIF1L
Allograft inflammatory factor 1-like
Also known as: AIF1L_HUMAN, C9orf58, FLJ12783, IBA2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BQI0
- Gene
- AIF1L
- Ensembl
- ENSG00000126878
- Chromosome
- 9
- Canonical length
- 150 aa
- Protein class
- Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables actin filament binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Located in actin filament and focal adhesion. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
150 residues, UniProt reviewed canonical sequence.
>Q9BQI0|AIF1L
1 MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT AFKEKYMEFD
61 LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS DTISYRDFVN MMLGKRSAVL
121 KLVMMFEGKA NESSPKPVGP PPERDIASLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against AIF1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 358 nTPM
Expression across tissuesHPA
Tissue
- kidney: 358 nTPM
- spinal cord: 262 nTPM
- spleen: 195 nTPM
- midbrain: 192 nTPM
- hippocampal formation: 146 nTPM
- basal ganglia: 140 nTPM
Single-cell type
- esophageal apical cells: 2,988 nCPM
- extravillous trophoblasts: 590 nCPM
- breast lactating cells: 271 nCPM
- renal collecting duct principal cells: 212 nCPM
- renal connecting tubule cells: 173 nCPM
- loop of henle epithelial cells: 162 nCPM
Immune cell
- NK-cell: 0.4 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 270 nTPM
- medulla oblongata: 240 nTPM
- midbrain: 229 nTPM
- basal ganglia: 216 nTPM
- pons: 214 nTPM
- thalamus: 194 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.02
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads AIF1L as an antibody target. Whether an autoantibody or antibody against AIF1L could matter depends on whether native AIF1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
AIF1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label AIF1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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