Seroatlas · Human Serome Atlas

AHSA2P

Putative activator of 90 kDa heat shock protein ATPase homolog 2

Also known as: AHSA2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q719I0
Gene: AHSA2P
Canonical length: 299 aa

OverviewNCBI Gene

No narrative summary is available for AHSA2P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q719I0|AHSA2P
     1  MAKWGQGNPH WIVEEREDGT NVNNWRWTER DATSLSKGKF QELLVGIVVE NDAGRGEINE
    61  LKQVEGEASC SSRKGKLIFF YEWNIKLGWK GIVKESGVKH KGLIEIPNLS EENEVDDTEV
   121  SLSKKKGDGV ILKDLMKTAG TAKVREALGD YLKALKTEFT TGMILPTKAM ATQELTVKRK
   181  LSGNTLQVQA SSPVALGVRI PTVALHMMEL FDTTVEQLYS IFTVKELTNK KIIMKWRCGN
   241  WPEEHYAMVA LNFVPTLGQT ELQLKEFLSI CKEENMKFCW QKQHFEEIKG SLQLTPLNG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHSA2P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHSA2P as an antibody target. Whether an autoantibody or antibody against AHSA2P could matter depends on whether native AHSA2P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHSA2P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHSA2P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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