Seroatlas · Human Serome Atlas

AHNAK2

Protein AHNAK2

Also known as: AHNK2_HUMAN, C14orf78

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVF2
Gene
AHNAK2
Ensembl
ENSG00000185567
Chromosome
14
Canonical length
5795 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

5795 residues, UniProt reviewed canonical sequence.

>Q8IVF2|AHNAK2
     1  MCDCFHMVLP TWPGTPGSVS GRQLQPGEPG AETEDDHSVT EGPADEGIRP RPQGSSPVYE
    61  YTTEAADFGL QEDAPGRQGS AGRRRSWWKR DSGDSRTFFR MSRPEAVQEA TEVTLKTEVE
   121  AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL FNLREGDQLL STTVFFENIK YEDALKILQY
   181  SEPYKVQFKI RRQLPAPQDE EWASSDAQHG PQGKEKEDTD VADGCRETPT KTLEGDGDQE
   241  RLISKPRVGR GRQSQRERLS WPKFQSIKSK RGPGPQRSHS SSEAYEPRDA HDVSPTSTDT
   301  EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG QPGRGFQSGV GRAGVLEELG
   361  PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG DPRLCEGTPQ EGGLRAARLH
   421  GKTLEGQAQE TAVAQRKPRA QPTPGMSREG EGEGLQSLEI GIARLSLRDT TEGGTQIGPP
   481  EIRVRVHDLK TPKFAFSTEK EPERERRLST PQRGKRQDAS SKAGTGLKGE EVEGAGWMPG
   541  REPTTHAEAQ GDEGDGEEGL QRTRITEEQD KGREDTEGQI RMPKFKIPSL GWSPSKHTKT
   601  GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD SMTNTTKIQL IHDEKRLKKE
   661  QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV SAPKVEADVS LLSMQGDLKT
   721  TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE GASLKGHLPK VQRPSLKMPK VDLKGPKLDL
   781  KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKEVTAKD SKFKMPKFKM
   841  PSFGVSAPGK SMEDSVDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK
   901  LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDGEVS
   961  LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIKAL
  1021  VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP ASTDLKVQAD QVDVKLPEGH LPEGAGLKGH
  1081  LPKVEMPSFK MPKVALKGPQ VDVKGPKLDL KSPKAEVTAP DVEVSLPSVE VDVEAPGAKL
  1141  DSARLEGELS LADKDVTAKD SRFKMPKFKM PSFGASAPGK SIEASVDVSA PKVEADVSLP
  1201  SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA GFKGHLPKVQ MPSLKMPKVD
  1261  LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA PGAKLDGAQL DGDLSLADKD
  1321  VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDLSAPKVEA DMSLPSMQGD LKTTDLSIQP
  1381  PSTDLELQAG QLDVKLPEGP VPEGAGLKGH LPKLQMPSFK VPKVDLKGPE IDIKGPKLDL
  1441  KDPKVEVTAP DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS LADKDLTTKD SKFKMPKFKM
  1501  PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD LSIQPPSADL EVQAGQVDVK
  1561  LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKV EVTAPDVKMS
  1621  LSSMEVDVQA PRAKLDGAQL EGDLSLADKA VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS
  1681  VDVSEPKVEA DVSLPSMQGD LKTTDLSIQS PSADLEVQAG QVNVKLPEGP LPEGAGFKGH
  1741  LPKVQMPSLK MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP DVEVSLPSVE VDVEAPGAKL
  1801  DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA PKVEAEVSLP
  1861  SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA GLKGHLPKVD MPSFKMPKVD
  1921  LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS LPSMEVDVQA QKAKLDGARL EGDLSLADKD
  1981  MTAKDSKFKM PKFKMPSFGV SAPGRSIEAS VDVPAPKVEA DVSLPSMQGD LKTTDLSIQP
  2041  PSADLKVQTG QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL
  2101  KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT LANKDLTTKD SKFKMPKFKM
  2161  PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD LSIQPLSADV KVQAGQVDVK
  2221  LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS
  2281  LPSVEVDVKA PGAKLDGARL EGDMSLADKD VTAKDSKFKM PKFKMLSFGV SALGKSIEAS
  2341  ADVSALKVEA DVSLPSMQGD LKTTDLSVQP PSADLEVQAG QVDVKLPEGP VPEGAGLKGH
  2401  LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP DVEVSQPSVE VDVEAPGAKL
  2461  DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK SIEASVDVSA PKVEADGSLS
  2521  SMQGDLKATD LSIQPPSADL EVQAGQVDVK LPEGPVPEGA GLKGHLPKVQ MPSFKMPEMD
  2581  LKGPQLDVKG PKLDLKGPKA EVTAPDVEMS LSSMEVDVQA PRAKLDGARL EGDLSLADKG
  2641  VTAKDSKFKM PKFKMPSFRV SAPGESIEAL VDVSELKVEA DMSLPSMQGD LKTTDISIQP
  2701  PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK MPEVDLKGPQ IDVKGPNVDL
  2761  KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKGMTAKD SKFKMPKFKM
  2821  PSFGVSAPGK SIEASVDVSE LKVEADGSFP SMQGDLKTTD IRIQPPSAQL EVQAGQVDVK
  2881  LPEGHVPEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDVEVS
  2941  LPSVEVDVEA PRAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEVS
  3001  VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG QVDLKLPEGH VPEGAGLKGH
  3061  LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP DVEVSQPGME VDVEAPGAKL
  3121  DGARLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEVLVDVSA PKVEADLSLP
  3181  SMQGDLKNTD ISIEPPSAQL EVQAGQVDVK LPEGHVLEGA GLKGHLPKLQ MPSFKMPKVD
  3241  RKGPQIDIKG PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA PGAKLDGARL EGDLSLADKD
  3301  VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA DVSLPSMQGD LKTTDLSIQL
  3361  PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK MPKVDLKSPQ VDIKGPKLDL
  3421  KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL DGARLEGDLS LAEKDVTAKD SKFKMPKFKM
  3481  PSFGVSAPGR SIEASLDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAVQVDVE
  3541  LLEGPVPEGA GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG PKLDLKGPKA EVRVPDVEVS
  3601  LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM PKFKMPSFRV SAPGKSMEAS
  3661  VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG QMDVKLPEGQ VPEGAGLKEH
  3721  LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL KVSKAEVTAP DVEVSLPSVE VDVQAPRAKL
  3781  DSAQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVHVSA PKVEADVSLP
  3841  SMQGDLKTTD LSIQPHSADL TVQARQVDMK LLEGHVPEEA GLKGHLPKVQ MPSFKMPKVD
  3901  LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA PGAKLDGARL EGDLSLADKD
  3961  MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA DVSLPSMQGD LKATDLSVQP
  4021  PSADLEVQAG QVDVKLPEGP VPEGASLKGH LPKVQMPSFK MPKVDLKGPQ IDVKGPKLDL
  4081  KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGVQLEGDLS LADKDVTAKD SKFKMPKFKM
  4141  PSFGVSAPGK SMEASVDVSE LKAKADVSLP SMQGDLKTTD LSIQSPSADL EVQAGQVDVK
  4201  LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG PKLDLKGPKA DVMTPVVEVS
  4261  LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSIEAS
  4321  LDVSALKVEA DVSLPSMQGD LKTTHLSIQP PSADLEVQAG QEDVKLPEGP VHEGAGLKGH
  4381  LPKLQMPSFK VPKVDLKGPQ IDVNVPKLDL KGPKVEVTSP NLDVSLPSME VDIQAPGAKL
  4441  DSTRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGMLSPGK SIEVSVDVSA PKMEADMSIP
  4501  SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA GLKGHLPKVE MPSFKMPKVD
  4561  LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA PGSMLDGARL EGDLSLAHED
  4621  VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS EIEGNVTFHE KTSTFPIVES VVHEGDLHDP
  4681  SRDGNLGLAV GEVGMDSKFK KLHFKVPKVS FSSTKTPKDS LVPGAKSSIG LSTIPLSSSE
  4741  CSSFELQQVS ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE SSILSPCEDV TLTKYQVTVP
  4801  RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS QAESHSGPLN SMIPVSLGQV
  4861  SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE RVQCPLPSTQ LPSPGTCVSQ
  4921  GPEELVASLQ TSVVAPGEAP SEDADHEGKG SPLKMPKIKL PSFRWSPKKE TGPKVDPECS
  4981  VEDSKLSLVL DKDEVAPQSA IHMDLPPERD GEKGRSTKPG FAMPKLALPK MKASKSGVSL
  5041  PQRDVDPSLS SATAGGSFQD TEKASSDGGR GGLGATASAT GSEGVNLHRP QVHIPSLGFA
  5101  KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD VPVSQPCGEG IAPTPEDPLQ
  5161  PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL RRSFRDRGGA GKLEVAQTQA
  5221  PAATGGEAAA KVKEFLVSGS NVEAAMSLQL PEADAEVTAS ESKSSTDILR CDLDSTGLKL
  5281  HLSTAGMTGD ELSTSEVRIH PSKGPLPFQM PGMRLPETQV LPGEIDETPL SKPGHDLASM
  5341  EDKTEKWSSQ PEGPLKLKAS STDMPSQISV VNVDQLWEDS VLTVKFPKLM VPRFSFPAPS
  5401  SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG AGVPGEQPVD LNLPLEAPPI
  5461  SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI VRESEIPTSE IQTPSYGFSL
  5521  LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE APIQATPGVD SISGDLQPDT GEPFEMISSS
  5581  VNVLGQQTLT FEVPSGHQLA DSCSDEEPAE ILEFPPDDSQ EATTPLADEG RAPKDKPESK
  5641  KSGLLWFWLP NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE ARPEAELPKK QEKAGWFRFP
  5701  KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF SPEEKEEGEL IGPVGTGLDS
  5761  RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHNAK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
294 nTPM

Expression across tissuesHPA

Tissue

  • skin: 294 nTPM
  • esophagus: 111 nTPM
  • colon: 101 nTPM
  • vagina: 84 nTPM
  • cervix: 83 nTPM
  • endometrium: 63 nTPM

Single-cell type

  • esophageal apical cells: 426 nCPM
  • esophageal suprabasal cells: 299 nCPM
  • suprabasal keratinocytes: 254 nCPM
  • basal keratinocytes: 147 nCPM
  • smooth muscle cells: 135 nCPM
  • salivary duct cells: 123 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 86 nTPM
  • medulla oblongata: 80 nTPM
  • white matter: 38 nTPM
  • thalamus: 37 nTPM
  • hypothalamus: 33 nTPM
  • cerebral cortex: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-12
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AHNAK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHNAK2 as an antibody target. Whether an autoantibody or antibody against AHNAK2 could matter depends on whether native AHNAK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHNAK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHNAK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AHNAK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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