Seroatlas · Human Serome Atlas

AHI1-DT

Putative uncharacterized protein encoded by LINC00271

Also known as: CF217_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7V0
Gene: AHI1-DT
Canonical length: 271 aa

OverviewNCBI Gene

No narrative summary is available for AHI1-DT in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P0C7V0|AHI1-DT
     1  MLNSPGTRRP VKEAQKYGED SQKSHSPGTP GPRSSVTTLS ASALSDSSSP DTPPRRGPGR
    61  PSTPARAPAT SAPMMYSRRG VRRTARPAGA DTRSSANQLP QPSGACANAD SAPPADVSAC
   121  LRRRSHGDRC VPRSRRRPRP RPRASTAFFQ EEGPCGACPG ALRPQAGASF RELRGLPPPR
   181  PREREQSPPL GAAPSSALSH QGWKNTRCAT RGLVNTLVNT GHFLYLQPPA PLIMPYLDDA
   241  EVPGNRRSHP SLSFSWLSKA LYHVTFLLRI L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHI1-DT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHI1-DT as an antibody target. Whether an autoantibody or antibody against AHI1-DT could matter depends on whether native AHI1-DT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHI1-DT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHI1-DT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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