Seroatlas · Human Serome Atlas

AGPAT5

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

Also known as: FLJ11210, LPAAT-e, LPAAT-epsilon, LPLAT5, PLCE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUQ2
Gene
AGPAT5
Ensembl
ENSG00000155189
Chromosome
8
Canonical length
364 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9NUQ2|AGPAT5
     1  MLLSLVLHTY SMRYLLPSVV LLGTAPTYVL AWGVWRLLSA FLPARFYQAL DDRLYCVYQS
    61  MVLFFFENYT GVQILLYGDL PKNKENIIYL ANHQSTVDWI VADILAIRQN ALGHVRYVLK
   121  EGLKWLPLYG CYFAQHGGIY VKRSAKFNEK EMRNKLQSYV DAGTPMYLVI FPEGTRYNPE
   181  QTKVLSASQA FAAQRGLAVL KHVLTPRIKA THVAFDCMKN YLDAIYDVTV VYEGKDDGGQ
   241  RRESPTMTEF LCKECPKIHI HIDRIDKKDV PEEQEHMRRW LHERFEIKDK MLIEFYESPD
   301  PERRKRFPGK SVNSKLSIKK TLPSMLILSG LTAGMLMTDA GRKLYVNTWI YGTLLGCLWV
   361  TIKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGPAT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 19 nTPM
  • basal ganglia: 14 nTPM
  • amygdala: 14 nTPM
  • testis: 13 nTPM
  • midbrain: 13 nTPM
  • hippocampal formation: 13 nTPM

Single-cell type

  • ependymal cells: 155 nCPM
  • proximal tubule cells: 104 nCPM
  • microglia: 83 nCPM
  • oligodendrocyte progenitor cells: 76 nCPM
  • other brain neurons: 75 nCPM
  • astrocytes: 71 nCPM

Immune cell

  • naive B-cell: 5.1 nTPM
  • memory B-cell: 4.4 nTPM
  • plasmacytoid DC: 4.4 nTPM
  • NK-cell: 2.7 nTPM
  • intermediate monocyte: 2.4 nTPM
  • non-classical monocyte: 2.2 nTPM

Brain region

  • white matter: 12 nTPM
  • medulla oblongata: 11 nTPM
  • spinal cord: 10 nTPM
  • midbrain: 10 nTPM
  • hypothalamus: 9.9 nTPM
  • cerebellum: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGPAT5.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
-1.66
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGPAT5 as an antibody target. Whether an autoantibody or antibody against AGPAT5 could matter depends on whether native AGPAT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGPAT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGPAT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGPAT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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