Seroatlas · Human Serome Atlas

AGPAT4

1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Also known as: dJ473J16.2, LPAAT-delta, LPAAT4, LPLAT4, PLCD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRZ5
Gene: AGPAT4
Ensembl: ENSG00000026652
Chromosome: 6
Canonical length: 378 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q9NRZ5|AGPAT4
     1  MDLAGLLKSQ FLCHLVFCYV FIASGLIINT IQLFTLLLWP INKQLFRKIN CRLSYCISSQ
    61  LVMLLEWWSG TECTIFTDPR AYLKYGKENA IVVLNHKFEI DFLCGWSLSE RFGLLGGSKV
   121  LAKKELAYVP IIGWMWYFTE MVFCSRKWEQ DRKTVATSLQ HLRDYPEKYF FLIHCEGTRF
   181  TEKKHEISMQ VARAKGLPRL KHHLLPRTKG FAITVRSLRN VVSAVYDCTL NFRNNENPTL
   241  LGVLNGKKYH ADLYVRRIPL EDIPEDDDEC SAWLHKLYQE KDAFQEEYYR TGTFPETPMV
   301  PPRRPWTLVN WLFWASLVLY PFFQFLVSMI RSGSSLTLAS FILVFFVASV GVRWMIGVTE
   361  IDKGSAYGNS DSKQKLND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGPAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 53 nTPM
midbrain: 22 nTPM
hippocampal formation: 17 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 11 nTPM

Single-cell type

oligodendrocytes: 550 nCPM
monocytes: 236 nCPM
nk-cells: 213 nCPM
ocular epithelial cells: 186 nCPM
choroid plexus epithelial cells: 174 nCPM
lactotrophs: 163 nCPM

Immune cell

gdT-cell: 3.4 nTPM
NK-cell: 2.9 nTPM
memory CD8 T-cell: 2.1 nTPM
classical monocyte: 1.8 nTPM
T-reg: 1.7 nTPM
memory CD4 T-cell: 1.6 nTPM

Brain region

white matter: 116 nTPM
medulla oblongata: 113 nTPM
pons: 86 nTPM
basal ganglia: 76 nTPM
thalamus: 73 nTPM
midbrain: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.1
gnomAD missense Z: 2.23
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

1-acylglycerol-3-phosphate O-acyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGPAT4 as an antibody target. Whether an autoantibody or antibody against AGPAT4 could matter depends on whether native AGPAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGPAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGPAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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