Seroatlas · Human Serome Atlas

AGPAT3

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

Also known as: LPAAT-gamma, LPAAT3, LPLAT3, PLCC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRZ7
Gene: AGPAT3
Ensembl: ENSG00000160216
Chromosome: 21
Canonical length: 376 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q9NRZ7|AGPAT3
     1  MGLLAFLKTQ FVLHLLVGFV FVVSGLVINF VQLCTLALWP VSKQLYRRLN CRLAYSLWSQ
    61  LVMLLEWWSC TECTLFTDQA TVERFGKEHA VIILNHNFEI DFLCGWTMCE RFGVLGSSKV
   121  LAKKELLYVP LIGWTWYFLE IVFCKRKWEE DRDTVVEGLR RLSDYPEYMW FLLYCEGTRF
   181  TETKHRVSME VAAAKGLPVL KYHLLPRTKG FTTAVKCLRG TVAAVYDVTL NFRGNKNPSL
   241  LGILYGKKYE ADMCVRRFPL EDIPLDEKEA AQWLHKLYQE KDALQEIYNQ KGMFPGEQFK
   301  PARRPWTLLN FLSWATILLS PLFSFVLGVF ASGSPLLILT FLGFVGAASF GVRRLIGVTE
   361  IEKGSSYGNQ EFKKKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGPAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

retina: 58 nTPM
skeletal muscle: 57 nTPM
liver: 51 nTPM
spinal cord: 50 nTPM
kidney: 50 nTPM
small intestine: 49 nTPM

Single-cell type

rod photoreceptor cells: 323 nCPM
early spermatids: 314 nCPM
late spermatids: 293 nCPM
cone photoreceptor cells: 255 nCPM
proximal tubule cells: 239 nCPM
myonuclei: 202 nCPM

Immune cell

non-classical monocyte: 9.6 nTPM
intermediate monocyte: 7.4 nTPM
myeloid DC: 3.8 nTPM
classical monocyte: 3.3 nTPM
T-reg: 3 nTPM
eosinophil: 2.2 nTPM

Brain region

medulla oblongata: 131 nTPM
thalamus: 124 nTPM
spinal cord: 123 nTPM
white matter: 119 nTPM
basal ganglia: 118 nTPM
cerebellum: 109 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGPAT3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 2.54
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

1-acylglycerol-3-phosphate O-acyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGPAT3 as an antibody target. Whether an autoantibody or antibody against AGPAT3 could matter depends on whether native AGPAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGPAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGPAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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