Seroatlas · Human Serome Atlas

AGMAT

Guanidino acid hydrolase, mitochondrial

Also known as: FLJ23384, GDAH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSE5
Gene: AGMAT
Ensembl: ENSG00000116771
Chromosome: 1
Canonical length: 352 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables arginase activity; guanidinobutyrase activity; and guanidinopropionase activity. Predicted to be involved in putrescine biosynthetic process from arginine, via agmatine. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q9BSE5|AGMAT
     1  MLRLLASGCA RGPGPGVGAR PAAGLFHPGR RQSRQASDAP RNQPPSPEFV ARPVGVCSMM
    61  RLPVQTSPEG LDAAFIGVPL DTGTSNRPGA RFGPRRIREE SVMLGTVNPS TGALPFQSLM
   121  VADLGDVNVN LYNLQDSCRR IQEAYEKIVA AGCIPLTLGG DHTITYPILQ AMAKKHGPVG
   181  LLHVDAHTDT TDKALGEKLY HGAPFRRCVD EGLLDCKRVV QIGIRGSSTT LDPYRYNRSQ
   241  GFRVVLAEDC WMKSLVPLMG EVRQQMGGKP IYISFDIDAL DPAYAPGTGT PEIAGLTPSQ
   301  ALEIIRGCQG LNVMGCDLVE VSPPYDLSGN TALLAANLLF EMLCALPKVT TV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGMAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

kidney: 125 nTPM
liver: 58 nTPM
skeletal muscle: 32 nTPM
duodenum: 17 nTPM
small intestine: 13 nTPM
colon: 8.7 nTPM

Single-cell type

hepatocytes: 106 nCPM
gastric progenitor cells: 58 nCPM
proximal tubule cells: 46 nCPM
enteric transient amplifying cells: 41 nCPM
enterocytes: 41 nCPM
enteric stem cells: 38 nCPM

Immune cell

naive CD4 T-cell: 8.4 nTPM
T-reg: 6.4 nTPM
naive CD8 T-cell: 5 nTPM
memory CD4 T-cell: 4.5 nTPM
memory B-cell: 4.1 nTPM
MAIT T-cell: 2.6 nTPM

Brain region

cerebellum: 6.8 nTPM
cerebral cortex: 6.8 nTPM
hypothalamus: 6.5 nTPM
basal ganglia: 6.4 nTPM
white matter: 6.2 nTPM
choroid plexus: 6.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGMAT.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

agmatine biosynthetic process
urea cycle
putrescine biosynthetic process from arginine, via agmatine

Molecular functions

arginase activity
metal ion binding
agmatinase activity
guanidinobutyrase activity
guanidinopropionase activity

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGMAT as an antibody target. Whether an autoantibody or antibody against AGMAT could matter depends on whether native AGMAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGMAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGMAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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