Seroatlas · Human Serome Atlas

AGFG2

Arf-GAP domain and FG repeat-containing protein 2

Also known as: AGFG2_HUMAN, HRBL, RABR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95081
Gene
AGFG2
Ensembl
ENSG00000106351
Chromosome
7
Canonical length
481 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

481 residues, UniProt reviewed canonical sequence.

>O95081|AGFG2
     1  MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI
    61  TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS
   121  LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG
   181  DPAPSLSVAA STSSQPVSQS HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA
   241  PAFAAFPAFG GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF
   301  GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG GGGGSSTGLA
   361  FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG PGFPQAVPPT GAFASSFPAP
   421  LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL SQPAGISTNP FMTGPSSSPF ASKPPTTNPF
   481  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGFG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
272 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 272 nTPM
  • liver: 51 nTPM
  • adrenal gland: 34 nTPM
  • esophagus: 29 nTPM
  • ovary: 29 nTPM
  • spleen: 28 nTPM

Single-cell type

  • esophageal apical cells: 196 nCPM
  • salivary acinar cells: 175 nCPM
  • lacrimal acinar cells: 130 nCPM
  • epicardial cells: 107 nCPM
  • salivary myoepithelial cells: 68 nCPM
  • hepatocytes: 67 nCPM

Immune cell

  • basophil: 2.2 nTPM
  • eosinophil: 2.2 nTPM
  • memory CD8 T-cell: 2 nTPM
  • gdT-cell: 1.7 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • MAIT T-cell: 1.5 nTPM

Brain region

  • hippocampal formation: 53 nTPM
  • basal ganglia: 49 nTPM
  • medulla oblongata: 48 nTPM
  • amygdala: 43 nTPM
  • thalamus: 40 nTPM
  • cerebral cortex: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGFG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • EPS15R

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGFG2 as an antibody target. Whether an autoantibody or antibody against AGFG2 could matter depends on whether native AGFG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGFG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGFG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGFG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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