Seroatlas · Human Serome Atlas

AGBL5

Cytosolic carboxypeptidase-like protein 5

Also known as: CBPC5_HUMAN, CCP5, FLJ21839

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDL9
Gene: AGBL5
Ensembl: ENSG00000084693
Chromosome: 2
Canonical length: 886 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Primary cilium,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a """"""""""""""""""""""""""""""""dual-functional"""""""""""""""""""""""""""""""" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

886 residues, UniProt reviewed canonical sequence.

>Q8NDL9|AGBL5
     1  MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP DYEFNVWTRP
    61  DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK LYSQGMAPFV RTLPTRPRWE
   121  RIRDRPTFEM TETQFVLSFV HRFVEGRGAT TFFAFCYPFS YSDCQELLNQ LDQRFPENHP
   181  THSSPLDTIY YHRELLCYSL DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA
   241  GKRIFFLSSR VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG
   301  HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH QPSSCLPPDA
   361  PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN SVWIMPQQSA GLEESAPDTI
   421  PPKESGVAYY VDLHGHASKR GCFMYGNSFS DESTQVENML YPKLISLNSA HFDFQGCNFS
   481  EKNMYARDRR DGQSKEGSGR VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP
   541  PPPPAFPSRY TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS
   601  RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG SSSSQQNSPQ
   661  MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS QDRRRQQQPL NHRPAGSLAP
   721  SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS CSLLSSGDKP EAVMVIGKGL LGTGARMPCI
   781  KTRLQARPRL GRGSPPTRRG MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR
   841  SAPAFSPISC SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGBL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 180 nTPM

Expression across tissuesHPA

Tissue

testis: 180 nTPM
parathyroid gland: 47 nTPM
thyroid gland: 27 nTPM
epididymis: 25 nTPM
kidney: 21 nTPM
salivary gland: 20 nTPM

Single-cell type

late spermatids: 555 nCPM
late primary spermatocytes: 405 nCPM
early spermatids: 284 nCPM
early primary spermatocytes: 72 nCPM
cardiomyocytes: 60 nCPM
undifferentiated spermatogonia: 56 nCPM

Immune cell

basophil: 8.8 nTPM
NK-cell: 8.6 nTPM
memory B-cell: 4.6 nTPM
memory CD8 T-cell: 4.6 nTPM
eosinophil: 4.5 nTPM
memory CD4 T-cell: 4.1 nTPM

Brain region

hypothalamus: 40 nTPM
choroid plexus: 37 nTPM
thalamus: 36 nTPM
pons: 35 nTPM
medulla oblongata: 35 nTPM
amygdala: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGBL5.

Disease | AllUniProt

Conditions AGBL5 is implicated in, by any mechanism.

Retinitis pigmentosa 75 (RP75) MIM:617023

Disease | GeneticClinVar

42 pathogenic / likely-pathogenic of 754 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Retinitis pigmentosa 75
Retinal dystrophy
Retinitis pigmentosa
Autosomal recessive retinitis pigmentosa

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M14, carboxypeptidase A
Cytosolic carboxypeptidase, N-terminal
Cytosolic carboxypeptidase
Zinc carboxypeptidase
Cytosolic carboxypeptidase N-terminal domain
Cytosolic carboxypeptidase-like protein 5 catalytic domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGBL5 as an antibody target. Whether an autoantibody or antibody against AGBL5 could matter depends on whether native AGBL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGBL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGBL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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