AGBL4

Protein identityUniProt · HPA

UniProt accession

Q5VU57

Gene

AGBL4

Ensembl

ENSG00000186094

Chromosome

1

Canonical length

503 aa

Protein class

Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in C-terminal protein deglutamylation; defense response to virus; and protein side chain deglutamylation. Predicted to act upstream of or within several processes, including axonal transport of mitochondrion; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of blastocyst development. Located in Golgi apparatus; centriole; and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q5VU57|AGBL4
     1  MAEGSQSAPE AGNDMGNDDA IGGNVSKYIV LPTGYCGQPK KGHLIFDACF ESGNLGRVDQ
    61  VSEFEYDLFI RPDTCNPRFR VWFNFTVENV KESQRVIFNI VNFSKTKSLY RDGMAPMVKS
   121  TSRPKWQRLP PKNVYYYRCP DHRKNYVMSF AFCFDREEDI YQFAYCYPYT YTRFQHYLDS
   181  LQKRNMDYFF REQLGQSVQQ RKLDLLTITS PDNLREGAEQ KVVFITGRVH PGETPSSFVC
   241  QGIIDFLVSQ HPIACVLREY LVFKIAPMLN PDGVYLGNYR CSLMGFDLNR HWLDPSPWVH
   301  PTLHGVKQLI VQMYNDPKTS LEFYIDIHAH STMMNGFMYG NIFEDEERFQ RQAIFPKLLC
   361  QNAEDFSYSS TSFNRDAVKA GTGRRFLGGL LDHTSYCYTL EVSFYSYIIS GTTAAVPYTE
   421  EAYMKLGRNV ARTFLDYYRL NPVVEKVAIP MPRLRNKEIE VQRRKEKSPP YKHPLLRGPA
   481  SNYPNSKGDK KSSVNHKDPS TPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGBL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

4.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.76

gnomAD pLI

0

gnomAD missense Z

1.32

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterograde axonal transport of mitochondrion
• C-terminal protein deglutamylation
• central nervous system neuron development
• defense response to virus
• negative regulation of cell population proliferation
• positive regulation of ubiquitin-dependent protein catabolic process
• protein deglutamylation
• protein side chain deglutamylation
• proteolysis
• regulation of blastocyst development
• retrograde axonal transport of mitochondrion

Molecular functions

• metallocarboxypeptidase activity
• tubulin binding
• zinc ion binding

Cellular components

• axon cytoplasm
• centriole
• ciliary basal body
• cytoplasm
• cytosol
• Golgi apparatus
• microtubule cytoskeleton

Protein domainsUniProt · Pfam · InterPro

• Peptidase M14, carboxypeptidase A
• Cytosolic carboxypeptidase, N-terminal
• Cytosolic carboxypeptidase
• Zinc carboxypeptidase
• Cytosolic carboxypeptidase N-terminal domain

KeywordsUniProt

• Carboxypeptidase
• Cell projection
• Cytoplasm
• Cytoskeleton
• Golgi apparatus
• Hydrolase
• Metal-binding
• Metalloprotease
• Protease
• Zinc

InteractionsUniProt · HPA

Protein binding partners of AGBL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYLK